使用靛青绿（ICG）和近红外荧光成像对于皮肤黑色素瘤的哨兵淋巴结（SLN）映射是一个有前途的选择。该研究的目标是比较ICG和蓝色染料在检测放射性同位素纳米胶体（技术-99）淋巴结方面的表现。在2018年4月至2022年6月期间，连续的293例患有皮肤黑色素瘤（Breslow厚度≥0.8mm）的患者接受了广泛局部切除和SLN活检。患者分为A组（ICG；n=122）和B组（蓝色染料；n=163）。所有患者在术前接受了SPECT / CT成像检查。比较了两组之间的SLN检测参数和并发症。共有285名患者有完整的数据并纳入分析。中位年龄为62.0岁（范围为10-91岁），其中139名（48.8%）为女性患者。平均Breslow厚度为2.6mm，89例（31.2%）患者有溃疡，179例（62.8%）患者有≥1mm2的有丝分裂。组A中每名患者检测到的SLN平均数量为1.58，组B为1.48。在A组和B组中，SLN检测率分别为96.7%和89.6％（p = 0.022），病理SLN检测率分别为92.3%和97.1％（p = 0.481）。ICG具有更高的SLN检测率和与蓝色染料相等的病理SLN检测率。ICG可能不劣于蓝色染料，并且是皮肤黑色素瘤SLN活检中的有用辅助方法。 © 2023. Society of Surgical Oncology.

The use of indocyanine green (ICG) and near-infrared fluorescence imaging is a promising option for sentinel lymph node (SLN) mapping in cutaneous melanoma. The study objective was to compare the performance of ICG and blue dye at detecting SLNs with radioisotope nanocolloid (technetium-99).Between April 2018 and June 2022, 293 consecutive patients with cutaneous melanoma (Breslow thickness ≥ 0.8 mm) underwent wide local excision and SLN biopsy. Patients were divided into group A (ICG; n = 122) and group B (blue dye; n = 163). All patients underwent SPECT/CT imaging preoperatively. SLN detection parameters and complications were compared between the groups.A total of 285 patients had complete data and were included in the analysis. The median age was 62.0 (range 10-91) years, and 139 (48.8%) were female patients. The mean Breslow thickness was 2.6 mm, 89 (31.2%) patients had ulceration, and 179 (62.8%) patients had mitosis ≥ 1 mm2. The mean number of SLNs detected per patient in group A was 1.58 and group B was 1.48. In groups A and B, the SLN detection rate was 96.7% versus 89.6% (p = 0.022) and the pathological SLN detection rate was 92.3% versus 97.1% (p = 0.481), respectively.ICG had a higher SLN detection rate and equal pathological SLN detection rate to blue dye. ICG may not be inferior to blue dye and is a useful adjunct to radioisotope in SLN biopsy in cutaneous melanoma.© 2023. Society of Surgical Oncology.