PDT（光动力疗法）中聚集引起的猝灭、药物过早释放和缺氧引起的耐药性是设计和制备新型卟啉类光敏剂的挑战。本研究通过可逆加成-断裂链转移聚合制备了一系列由亲水性聚糖聚合物块和含卟啉疏水性块组成的嵌段共聚物。这些高分子光敏剂能够产生单线态氧并对HepG2展现出出色的PDT效果，经过胆汁酸的加入可以进一步强化。与化疗相结合，将多柔比星（Dox）成功地装载到共聚物中，被观察到更具光毒性，这表明PDT和化疗的协同作用的治疗效果优于它们的简单组合。含半乳糖的光敏剂与细胞之间的特异性相互作用使得在体外与HepG2细胞相比，L929和MCF-7细胞内摄取的平均荧光指数（MFI）更高。这些高分子纳米平台为癌症治疗的协同治疗开辟了多样有效的途径。

The aggregation-caused quenching, premature drug release, and hypoxia-caused resistance of photodynamic therapy (PDT) are challenges in the design and preparation of novel porphyrin-containing photosensitizers. In this work, a series of block copolymers consisting of a hydrophilic glycopolymer block and a porphyrin-containing hydrophobic block were prepared via reversible addition-fragmentation chain transfer polymerization. The polymeric photosensitizers generate singlet oxygen and excellent PDT against HepG2, which can be strengthened by the addition of cholic acid. To combine with chemotherapy, doxorubicin (Dox) was successfully loaded into copolymers, which were observed to be more phototoxic, indicating that the therapeutic benefit of the synergistic effect of PDT and chemotherapy is better than their simple combination. The sugar-cell-specific interaction of galactose-containing photosensitizers results in a stronger mean fluorescent index (MFI) intracellular uptake in HepG2 cells in vitro compared to L929 and MCF-7 cells. These polymeric nanoplatforms present a versatile and effective avenue for developing synergistic therapy for cancer treatment.