佛手柑主要产于意大利南部（卡拉布里亚）的伊奥尼亚沿海地区，自1700年以来就因其香膏和药用特性而被广泛使用。植物化学分析已确认佛手柑汁液中富含黄酮类物质，包括黄酮和黄烷类糖苷，这些物质负责其有益效应。最近的研究表明，自然化合物与传统治疗相结合可提高抗癌疗法的功效。具有抗癌特性的天然化合物可以攻击癌细胞而不对健康细胞产生毒性。佛手柑可诱导细胞毒性和凋亡作用，防止各种癌细胞的增殖。本文旨在描述佛手柑的抗增殖、促凋亡、抗炎和抗氧化效应。信息来源包括PubMed、Web of Science和Google Scholar等数据库，使用“佛手柑”及“炎症”、“癌症”等关键词，检索2015年至2021年发表的数据。体外和体内研究提供了证据，不同形式的佛手柑（提取物、汁液、精油和多酚分数）可以影响多种机制并产生抗增殖、促凋亡、抗炎和抗氧化效应。考虑到佛手柑及其新配方的效应，我们肯定了其在人类中的合理使用，并说明了佛手柑如何在临床应用中发挥作用。众多研究评估了新的佛手柑配方的效应，这些配方可以通过改变佛手柑的治疗特性来影响吸收和最终效应，并增强对佛手柑的科学认识。

Context: Bergamot, mainly produced in the Ionian coastal areas of Southern Italy (Calabria), has been used since 1700 for its balsamic and medicinal properties. Phytochemical profiling has confirmed that bergamot juices are rich in flavonoids, including flavone and flavanone glycosides which are responsible for its beneficial effects.Objective: Recently, it was shown that the combination of natural compounds with conventional treatments improves the efficacy of anticancer therapies. Natural compounds with anticancer properties attack cancerous cells without being toxic to healthy cells. Bergamot can induce cytotoxic and apoptotic effects and prevent cell proliferation in various cancer cells.Methods: In this review, the antiproliferative, pro-apoptotic, anti-inflammatory, and antioxidant effects of bergamot are described. Information was compiled from databases such as PubMed, Web of Science, and Google Scholar using the key words 'bergamot' accompanied by 'inflammation' and, 'cancer' for data published from 2015-2021.Results: In vitro and in vivo studies provided evidence that different forms of bergamot (extract, juice, essential oil, and polyphenolic fraction) can affect several mechanisms that lead to anti-proliferative and pro-apoptotic effects that decrease cell growth, as well as anti-inflammatory and antioxidant effects.Conclusions: Considering the effects of bergamot and its new formulations, we affirm the importance of its rational use in humans and illustrate how bergamot can be utilized in clinical applications. Numerous studies evaluated the effect of new bergamot formulations that can affect the absorption and, therefore, the final effects by altering the therapeutic profile of bergamot and enhancing the scientific knowledge of bergamot.