本文报道了一种新型三元生物聚合物基纳米海绵的工程，由交联 β-环糊精乙二胺（βCD-EDA）和双功能毛状纳米纤维素（BHNC）聚合而成。我们将高度交联的聚合物化BHNC-βCD-EDA网络称为BBE。βCD-EDA和BHNC在脱离离子水作为溶剂的情况下通过DMTMM（4-(4,6-二甲氧基-1,3,5-三嗪-2-基)-4-甲基吗啉）作为绿色催化剂以不同的比例进行交联，从而得到具有不同形态的BBE。由于交联液晶结构，其中一些结构呈手性。进行全面的表征研究，展示了BBE的独特形态，结构和尺寸特性。此外，为了进一步研究和确认前体和最终BBE结构的表面修饰，应用了傅里叶变换红外光谱和核磁共振谱，热重分析，布鲁诺-艾米特-泰勒分析和X射线衍射。毛状纳米纤维素颗粒被认为是骨架，而固定的环糊精空腔可通过主-客体包含复合物捕获某些药物分子，例如多柔比星。最终得到的BBE网络表现出不同和持续的药物释放特性和PH响应性。BBE生物聚合物被用作控制释放的生物兼容性纳米载体进行了测试。我们认识到，这些结构对于通过注射或口服进行抗癌药物输送来说太大了，但这些结构在创面敷料和植入物上具有很高的应用潜力。它们也可以用于从废水中捕获抗生素，染料和有机化合物。

The engineering of a new type of trifunctional biopolymer-based nanosponges polymerized by cross-linking beta-cyclodextrin ethylene diamine (βCD-EDA) with bifunctional hairy nanocellulose (BHNC) is reported herein. We refer to the highly cross-linked polymerized BHNC-βCD-EDA network as BBE. βCD-EDA and BHNC were cross-linked at various ratios with the help of DMTMM (4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium) as a green activator in deionized water as a solvent, which resulted in different morphological shapes of BBE. Some of these structures were chiral due to cross-linked liquid crystalline structures. A comprehensive characterization study was done to show their unique morphological, structural, and dimensional properties of BBEs. Moreover, to further investigate and to confirm the surface modification of the precursors and final BBE structures, Fourier transform infrared and nuclear magnetic resonance spectroscopy, thermogravimetric analysis, Brunauer-Emmett-Teller analysis, and X-ray diffraction were applied. The hairy nanocellulose particles were considered as the backbone, and the immobilized cyclodextrin cavities can capture doxorubicin, which was used as a model drug molecule via host-guest inclusion complexation. Finally, the obtained BBE networks showed different and sustained drug release profiles and pH responsiveness. BBE biopolymers were tested as biocompatible nanocarriers for controlled release. We realize that these structures are too big for anti-cancer drug delivery by injection or oral intake, but these structures have a high potential to be applied in wound dressing and implants. They could also be used for capturing antibiotics, dyes, and organic compounds from wastewater.