枸杞多糖(LBP)是从枸杞提取出的一种具有多种生物活性的物质。LbGP是一种寡肽聚糖，具有短的肽骨架和复杂的分支糖基，可以从LBPs中进一步提取和分离。以前的研究表明，LbGP可以抑制癌细胞生长，但其具体机制尚不完全清楚。在本研究中，我们发现LbGP可以通过PKA-CREB途径抑制胶质瘤细胞增殖并促进期2 (PER2)的表达。此外，LbGP可以通过下调SREBP1c及其靶基因的表达来抑制脂类的新生，其依赖于PER2的表达。此外，PER2通过抑制PI3K/AKT/mTOR途径，负向调节SREBP1c的表达。总之，LbGP可能通过上调PER2的表达来减少SREBP1c的表达，在胶质母细胞瘤中抑制脂类的合成，从而抑制胶质母细胞瘤的细胞增殖。本研究为胶质母细胞瘤的治疗提供了一种替代药物，并阐明了其潜在机制。©2023. 作者。

Lycium barbarum polysaccharide (LBP) is a substance with various biological activities extracted from Lycium barbarum. LbGPs are peptidoglycans with a short peptide backbone and a complex, branched glycan moiety, which is further extracted and isolated from LBPs. Previous studies have shown that LbGP can inhibit cancer cell growth, but its specific mechanism is not completely clear. In this study, we found that LbGP could inhibit the proliferation of glioma cells and promote the expression of period 2 (PER2) through the PKA-CREB pathway. In addition, LbGP could inhibit the de novo synthesis of lipids by downregulating SREBP1c and its target genes, which depended on the expression of PER2. Moreover, PER2 negatively regulated the expression of SREBP1c via suppressing PI3K/AKT/mTOR pathway. In summary, LbGP may upregulate the expression of PER2 to reduce the expression of SREBP1c, inhibit lipid synthesis in glioblastoma, and inhibit glioblastoma cell proliferation. This study provides an alternative drug for the treatment of glioma and elucidates its potential mechanism.© 2023. The Author(s).