针对Zawar和Kapur最近对内侧颞叶癫痫（MTLE）和阿尔茨海默病（AD）重叠的评论，我们（1）强调癫痫和痴呆之间的双向性非常有趣，也是癫痫学角度的；（2）概述了癫痫认知缺陷的多因素病因；（3）强调MTLE中最普遍的神经病理学发现包括海马硬化、畸形病变和神经发育性肿瘤；以及（4）指出抗癫痫药物也可能对认知产生不良影响。我们得出的结论是，MTLE的神经心理学和神经病理学实际上比Zawar和Kapur的评论暗示的更为复杂。他们提出的模型可能适用于一小部分特定病例。然而，需要更多的研究来确认高磷酸化tau在癫痫患者中的作用，并考虑年龄和癫痫发作年龄作为潜在的调节变量。©2023年作者。Alzheimer's＆Dementia由Wiley Periodicals LLC代表阿尔茨海默协会出版。

In response to the recent review by Zawar and Kapur on the overlap between mesial temporal lobe epilepsy (MTLE) and Alzheimer's disease (AD), we (1) underscore that the bidirectionality between epilepsy and dementia is of high interest, also from the epileptological perspective; (2) outline the multifactorial etiology of cognitive deficits in epilepsy; (3) emphasize that the most prevalent neuropathological findings in MTLE comprise hippocampal sclerosis, dysplastic lesions, and neurodevelopmental neoplasm; and (4) state that anti-seizure medication can also have adverse effects on cognition. We conclude that the neuropsychology and neuropathology of MTLE is actually more complex than implicated in the review by Zawar and Kapur. Their suggested model may be valid for a small specific subgroup of cases. However, more studies are needed to confirm the role of hyperphosphorylated tau in epilepsy patients with and without AD considering age and age at epilepsy onset as potential moderator variables.© 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.