慢性炎症及同时出现的氧化应激会增加癌症发展的风险。本研究旨在分析卵巢和子宫内膜癌症患者中的特定细胞因子和抗氧化酶，考虑肿瘤治疗的阶段。研究样本包括52名接受化疗的晚期子宫内膜癌（n = 26.50％）和卵巢癌（n = 26.50％）的女性患者。通过四个时点对受试者进行长期观察。每个女性都在手术前，以及在化疗的第一、第三和第六个周期前进行了多次血液采样，以确定血清前列腺素和抗炎细胞因子和抗氧化酶的水平。催化酶（CAT），谷胱甘肽还原酶（GR），白细胞介素（IL）-10，IL-1α，IL-4的水平因治疗阶段和癌症类型而异。卵巢癌患者的血清水平中IL-4和IL-10的含量明显高于子宫内膜癌患者。测试的抗氧化酶活性会随着化疗周期的不同而变化。在大多数情况下，它们的最高活性在第三个周期的化疗前观察到，而在第六个周期前降低，而与癌症类型无关。在研究对象中，卵巢癌和子宫内膜癌患者的化疗显著改变了某些白细胞介素和抗氧化酶的浓度和活性。肿瘤类型决定了治疗前IL-4和IL-10的水平。评估生殖器癌症女性的炎症参数和氧化应激可能有助于理解该治疗产生的生理变化。

Chronic inflammation along with concomitant oxidative stress contributes to an increased risk of cancer development. The aim of this study was to analyze selected cytokines and antioxidant enzymes in patients with ovarian and endometrial cancers, taking into account the stage of oncological treatment.The study sample included 52 female patients with advanced endometrial cancer (n = 26.50%) and ovarian cancer (n = 26.50%), undergoing chemotherapy. Long-term observation at four time points was used in the subjects. Each of the women was blood sampled several times (before surgery, and then before the first, third, and sixth cycle of chemotherapy) in order to determine serum levels of pro- and anti-inflammatory cytokines and antioxidant enzymes.The levels of catalase (CAT), glutathione reductase (GR), interleukin (IL)-10, IL-1α, IL-4 differed significantly depending on the stage of therapy and the type of cancer. The serum levels of IL-4 and IL-10 in patients with ovarian cancer were statistically significantly higher than those observed in patients with endometrial cancer. The activity of the tested antioxidant enzymes varied depending on the chemotherapy cycle. Their highest activity in most cases was observed before the third cycle of chemotherapy, and it decreased before the sixth cycle, irrespective of the type of cancer.In the studied group of patients with ovarian and endometrial cancer, the applied chemotherapy significantly changed the concentration and activity of some interleukins and antioxidant enzymes. The type of tumor determined the levels of IL-4 and IL-10 before the treatment. Evaluation of inflammatory parameters and oxidative stress in women with cancer of the reproductive organ may help to understand physiological changes resulting from the applied therapy.