非小细胞肺癌（NSCLC）是肺癌最普遍的形式。研究已经评估了社会卫生决定因素（SDH）与早期NSCLC结果的关联。这些研究显示了总生存期（OS）和其他SDH（例如婚姻状况、教育程度）之间存在显著的统计学和临床相关性。我们研究的目的是更好地了解各种SDH在佛罗里达州社区肿瘤实践中晚期NSCLC患者中的OS作用。方法：在这个回顾性研究中，从2014年1月1日到2018年12月31日之间确定了125例III期和IV期NSCLC患者。我们执行Pearson卡方和Kruskal-Wallis检验以评估中位OS和几个独立变量之间的关联，包括性别，种族，婚姻状况，保险状况，生活状况，接受财政援助（FA），饮酒和吸烟历史。 OS定义为诊断日期到死亡日期。其他分析的混杂因素包括组织学、治疗方式、合并症和患者的表现状况。结果：我们的结果表明，接受FA的患者与未接受FA的患者相比，中位OS增加了近两倍（中位OS=1.01年对0.545年，分别；P=0.012）。总之，这项研究突显了在患有晚期NSCLC的患者身上减轻经济负担的重要性以及FA如何影响患者的结果。然而，未来需要进行具有更大样本量的前瞻性队列研究来确定其他SDH以及影响晚期NSCLC患者中位OS的潜在机制。版权所有©2023，Bello等人。

Non-small cell lung cancer (NSCLC) is the most prevalent form of lung cancer. Studies have evaluated the association of social determinants of health (SDH) with outcomes in early-stage NSCLC. These studies have shown statistically and clinically significant associations between overall survival (OS) and other SDH (e.g marital status, educational attainment).The aim of our study was to better understand the role of various SDH on OS in advanced-stage NSCLC patients in a community oncology practice in Florida.  Methods: In this retrospective study, 125 patients with stage III and IV NSCLC were identified between January 1, 2014, and December 31, 2018. We performed Pearson's chi-square and Kruskal-Wallis test to evaluate the association between median OS and several independent variables, including; gender, race, marital status, insurance status, living status, receiving financial assistance (FA), alcohol use, and smoking histories. OS is defined as the date of diagnosis up to the date of death. Other confounders that were analyzed included histology, treatment modality, comorbidities, and performance status of the patients.  Results: Our results demonstrated that patients receiving FA had nearly a two-fold increase in median OS compared to patients without FA (median OS = 1.01 years vs. 0.545 years, respectively; p = 0.012).Overall, this study highlighted the importance of reducing the financial burden of advanced-stage NSCLC on patients and how FA impacts patient outcomes. However, future prospective cohort studies with a larger sample size are warranted to identify other SDH, as well as the underlying mechanisms affecting median OS, in patients with advanced-stage NSCLC.Copyright © 2023, Bello et al.