作为一种类似于泛素的蛋白质，神经前体细胞发育下调蛋白8 (NEDD8) 参与了neddylation，这种修饰和泛素化的底物相似，改变了靶蛋白的活性。 Neddylation 可能会影响多条信号通路的活性，在肿瘤生成、发展和转移中发挥调节作用，并影响癌症治疗的预后。本综述概述了NEDD8在MDM2-p53、NF-κB、PI3K/AKT/mTOR、缺氧诱导因子、海马细胞和受体酪氨酸激酶信号通路中的调节作用，以及在肺癌的发展和进展中的作用。

As a protein that resembles ubiquitin, neural precursor cell expressed developmentally downregulated 8 (NEDD8) takes part in neddylation, which modifies substrates in a manner similar to ubiquitination and alters the activity of target proteins. Neddylation may affect the activity of multiple signaling pathways, have a regulatory role in tumor formation, progression and metastasis, and influence the prognosis of cancer treatment. The present review summarizes the regulatory roles of NEDD8 in the MDM2‑p53, NF‑κB, PI3K/AKT/mTOR, hypoxia‑inducible factor, Hippo and receptor tyrosine kinase signaling pathways, as well as in the development and progression of lung cancer.