本研究调查了手术治疗对日本结直肠癌（CRC）患者健康相关生命质量（HRQOL）的影响。这项三机构队列研究包括106名CRC日本患者（男性69人；平均年龄：62.6 ± 12.4岁；年龄范围= 30-85岁）。使用Short-Form 36-Item Health Survey版本2在手术前一到两天（基线）和手术后四周评估HRQOL。调查了基线时的临床特征、社会特征和HRQOL。与基线相比，身体机能、身体角色、身体疼痛和社交功能在手术后四周显著下降，而心理健康显著改善。身体机能和一般健康状况感觉在手术后四周与六分钟步行测试（6MWT）和基线HRQOL评分有着特别强的关系。对于临床相关改善的6MWT截止值为物理机能552.5米（曲线下面积[AUC]= 0.780，95％置信区间[CI]= 0.692-0.867）和一般健康状况感觉480.3米（AUC = 0.721，95% CI = 0.626-0.817）。 CRC患者可能通过术后增加步行能力来提高术后HRQOL，并且他们在出院后可能需要随访干预，例如体育康复治疗。结果为改善日本CRC患者的HRQOL提供了一个潜在途径。

This study investigated the impact of surgical treatment on the health-related quality of life (HRQOL) of Japanese patients with colorectal cancer (CRC).This three-institution cohort study included 106 Japanese patients with CRC (69 men; mean age: 62.6 ± 12.4 years; age range = 30-85 years). HRQOL was evaluated using the Short-Form 36-Item Health Survey version 2 one to two days prior to surgery (baseline) and four weeks after surgery. Clinical characteristics, social characteristics, and HRQOL at baseline were investigated.Physical functioning, role-physical, bodily pain, and social functioning decreased significantly at four weeks after surgery compared with baseline, whereas mental health significantly improved. Physical functioning and general health perception showed an especially strong relation with the six-minute walk test (6MWT) at four weeks after surgery and HRQOL scores at baseline. The cutoff value for the 6MWT for clinically relevant improvement was 552.5 meters for physical functioning (area under curve [AUC] = 0.780, 95% confidence interval [CI] = 0.692-0.867) and 480.3 meters for general health perception (AUC = 0.721, 95% CI = 0.626-0.817).Patients with CRC could potentially improve their postoperative HRQOL by increasing their walking capacity post-surgery, and they may need follow-up interventions after discharge such as physical rehabilitation to do so. The results provide a potential pathway for improving HRQOL of Japanese patients with CRC.