近期接受嵌合抗原受体T细胞治疗的患者，核素PET/CT评估复杂化的结核病新发。
New Onset of Tuberculosis Complicating FDG PET/CT Evaluation in Patient With Recent Chimeric Antigen Receptor T-Cell Therapy.
发表日期：2023 Apr 17
作者：
Guanyun Wang, Xu Yang, Hongrong Wang, Wei Wang, Jigang Yang
来源：
CLINICAL NUCLEAR MEDICINE
摘要：
一名16岁的青少年女孩因急性淋巴细胞白血病接受CD19嵌合抗原受体（CAR）T细胞疗法，随之出现新发热。CAR-T治疗后1个月和2个月分别进行的18F-FDG PET / CT研究显示纵隔淋巴结出现异常活动，而治疗前未见异常。然而，这些异常活动的灶后来被证明是CAR-T细胞疗法后新发结核病。版权所有©2023 Wolters Kluwer Health，Inc。保留所有权利。
A 16-year-old adolescent girl with CD19 chimeric antigen receptor (CAR) T-cell therapy for acute lymphoblastic leukemia experienced new onset of the fever. 18F-FDG PET/CT studies acquired at 1 and 2 months, respectively, after CAR-T, showed foci of abnormal activity in the mediastinal lymph nodes not seen on the study before therapy. However, these foci of abnormal activity were later proven due to newly developed tuberculosis after CAR T-cell therapy.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.