一名78岁的男性患有前列腺癌和肺腺癌，他接受了[18F]F-前列腺特异性膜抗原（PSMA）1007 PET/CT检查以评估前列腺癌分期。除了已知的右肺损害外，PSMA靶向PET/CT检测出两个异常吸收区，位于左额叶和颞叶大脑内。随后进行的MRI证实了PET/CT观察到的损害。由于PSMA靶向放射性制剂不会在健康大脑实质中积累，并且最近的文献报道了PSMA靶向PET/CT在胶质瘤和前列腺癌以外其他肿瘤的转移中的良好表现，因此有必要进一步探索PSMA放射配体的应用。Copyright © 2023 Wolters Kluwer Health，Inc.保留所有权利。

A 78-year-old man with synchronous diagnosis of prostate cancer and lung adenocarcinoma was referred to our institute for prostate cancer staging with [18F]F-prostate-specific membrane antigen (PSMA) 1007 PET/CT. In addition to the previously known lesion of the right lung, PSMA-targeted PET/CT highlighted 2 areas of abnormal uptake in the brain, in the left frontal and temporal lobes. A subsequent MRI confirmed the lesions observed on PET/CT. Because PSMA-targeting radiopharmaceuticals do not accumulate in healthy brain parenchyma, and recent literature reported promising performances of PSMA-targeted PET/CT in gliomas and metastases from tumors other than prostate cancer, this employment of PSMA radioligands needs to be further explored.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.