cGAS-STING信号通路能够感知到胞质DNA的存在，诱导强烈的一型干扰素反应，并增强炎性细胞因子的产生，从而成为感染、自身免疫和抗肿瘤免疫的重要轴线。最近的研究表明，cGAS-STING信号的异常和/或功能失调与皮肤疾病和/或癌症的发病密切相关。此外，有各种针对cGAS-STING信号通路的新型治疗药物正在开发用于治疗皮肤疾病。然而，cGAS-STING介导的皮肤疾病的确切分子机制尚未完全阐明。在本综述中，我们将总结cGAS-STING信号在皮肤疾病中的调节作用和机制，以及cGAS-STING相关药物的最新进展及其潜在的临床应用。© 2023年 Springer Science + Business Media，LLC的作者，Springer Nature的一部分，独家许可。

The cGAS-STING signaling pathway senses the presence of cytosolic DNA, induces strong type I interferon responses, and enhances inflammatory cytokine production, placing it as an important axis in infection, autoimmunity, and tumor immunity. Recent studies have shown that the abnormalities and/or dysfunctions of cGAS-STING signaling are closely related to the pathogenesis of skin diseases and/or cancers. Additionally, a variety of new therapeutics targeting the cGAS-STING signaling are in development for the treatment of skin disorders. However, the precise molecular mechanisms of cGAS-STING-mediated cutaneous disorders have not been fully elucidated. In this review, we will summarize the regulatory roles and mechanisms of cGAS-STING signaling in skin disorders and recent progresses of cGAS-STING-related drugs as well as their potential clinical applications.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.