本次评述的目的是总结骨细胞在癌症患者、肌肉萎缩、脊髓损伤、杜氏肌萎缩症和其他与肌肉退化相关的疾病中发挥作用的情况。一种名为骨细胞的骨细胞似乎在肌肉和骨骼相互作用中发挥了至关重要的作用，不管是生理还是病理。骨细胞是生活在骨-矿质基质中的细胞。这些细胞通过树突相互连接，形成一个复杂的联网。骨细胞网络已被证明能够通过产生骨细胞源性因子来对机械解载、固定、衰老和癌症等不同类型的刺激做出反应。现在已经变得清楚，其中一些因子，包括硬化蛋白、RANKL、TGF-β和TNF-α对骨骼肌有不良影响。骨骼和肌肉不仅在机械上进行交流，还在生化上交流。骨细胞来源的因子似乎为肌肉疾病的发病机制作出了贡献，并可以作为新型治疗方法的细胞靶点使用。 ©2023年，作者（们）独家授权Springer Science+Business Media, LLC，Springer Nature的组成部分。

The purpose of this review is to summarize the role of the osteocyte in muscle atrophy in cancer patients, sarcopenia, spinal cord injury, Duchenne's muscular dystrophy, and other conditions associated with muscle deterioration.One type of bone cell, the osteocyte, appears to play a major role in muscle and bone crosstalk, whether physiological or pathological. Osteocytes are cells living within the bone-mineralized matrix. These cells are connected to each other by means of dendrites to create an intricately connected network. The osteocyte network has been shown to respond to different types of stimuli such as mechanical unloading, immobilization, aging, and cancer by producing osteocytes-derived factors. It is now becoming clear that some of these factors including sclerostin, RANKL, TGF-β, and TNF-α have detrimental effects on skeletal muscle. Bone and muscle not only communicate mechanically but also biochemically. Osteocyte-derived factors appear to contribute to the pathogenesis of muscle disease and could be used as a cellular target for new therapeutic approaches.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.