环状的nigerosylnigerose 减轻高脂饮食引起的脂肪沉积、结肠炎症和异常葡萄糖代谢，并修改肠道免疫球蛋白A对共生菌的反应。
Cyclic nigerosylnigerose attenuates high-fat diet-induced fat deposition, colonic inflammation, and abnormal glucose metabolism and modifies gut immunoglobulin A reactivity to commensal bacteria.
发表日期：2023 Apr 21
作者：
Takeshi Tsuruta, Kei Sonoyama, Taisei Miyamoto, Qui D Nguyen, Akiko Mizote, Mao Teraoka, Naoki Nishino
来源：
Food & Function
摘要：
高脂饮食（HFD）会导致肠道失调、周围组织炎症和肠道细菌免疫球蛋白A（IgA）涂层的减少，与HFD诱导的胰岛素抵抗（IR）有关。本研究评估了环状棕糖二糖（CNN）的作用，在HFD诱导的这种疾病中，CNN是能够预防肠道炎症和促进肠道细菌的IgA涂层的一种膳食纤维。Balb/c小鼠被喂养HFD并灌胃CNN 20周。CNN的神经系统控制减轻了内脏脂肪组织重量、结肠肿瘤坏死因子α（TNFα）mRNA表达和血清内毒素水平，并改善了HFD引起的异常葡萄糖代谢。此外，CNN管理推进肠道菌株特异性IgA分泌，并改变了对肠道细菌的IgA反应性。对IgA反应性对特定细菌的变化，如Erysipelatoclostridium，大肠杆菌，Faecalibaculum，Lachnospiraceae属和Stenotrophomonas与内脏脂肪组织重量，结肠TNFα mRNA表达，血清内毒素水平和IR的homeostasis模型评估有关。CNN诱导的对肠道细菌IgA反应性的改变可能与抑制HFD诱导的脂肪沉着，结肠炎症，内毒素血症和IR有关。我们的观察表明，调节IgA对肠道细菌反应的膳食纤维可能有助于预防HFD引起的疾病。此文章受版权保护，版权所有。
High-fat diet (HFD) intake induces gut dysbiosis, inflammation in the peripheral tissues, and a reduction in immunoglobulin A (IgA) coating of gut bacteria, which is related to HFD-induced insulin resistance (IR). In this study, we evaluated the effect of cyclic nigerosylnigerose (CNN), a dietary fiber that prevents gut inflammation and promotes IgA coating of gut bacteria, on the above-mentioned HFD-induced disorders.Balb/c mice were fed a HFD and administered CNN for 20 weeks. CNN administration reduced mesenteric adipose tissue weight, colonic tumor necrosis factor α (TNFα) mRNA expression, and serum endotoxin levels and ameliorated HFD-induced abnormal glucose metabolism. Additionally, CNN administration promoted gut bacteria-specific IgA secretion and altered IgA reactivity to gut bacteria. The alterations of IgA reactivity to specific bacteria such as Erysipelatoclostridium, Escherichia, Faecalibaculum, Lachnospiraceae genera, and Stenotrophomonas were correlated with mesenteric adipose tissue weight, colonic TNFα mRNA expression, serum endotoxin levels, and a homeostasis model assessment for IR.CNN-induced alterations in IgA reactivity to gut bacteria may be related to the suppression of HFD-induced fat deposition, colonic inflammation, endotoxemia, and IR. Our observations indicate that dietary fiber that modulates IgA reactivity to gut bacteria may be useful in preventing HFD-induced disorders. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.