将信号放大器降解：以ITK为靶点进行定向蛋白质降解。
Degrading the signal amplifier: ITK as a target for targeted protein degradation.
发表日期：2023 Apr 20
作者：
Avery August
来源：
Cell Chemical Biology
摘要：
在这份《Cell Chemical Biology》的期刊中，江等人首次展示了可以使用PROTAC方法靶向Tec激酶ITK。这种新的模式对于治疗T细胞淋巴瘤具有重要意义，但也有可能用于治疗依赖于ITK信号的T细胞介导的炎症性疾病。版权所有©2023 Elsevier Ltd.。
In this issue of Cell Chemical Biology, Jiang and colleagues show for the first time that the Tec kinase ITK can be targeted using PROTAC approaches. This new modality has implications for the treatment of T cell lymphomas, but also potentially for the treatment of T cell-mediated inflammatory diseases, that depend on ITK signaling.Copyright © 2023 Elsevier Ltd. All rights reserved.