结直肠癌是一种世界范围内高死亡率的常见癌症之一。类黄酮等多酚化合物是植物次生代谢产物，具有抗癌和抗炎作用。然而，由于它们的疏水性、易降解性和低生物利用度，治疗效果较差。纳米传递系统，如纳米脂质体，纳米胶束，硅胶纳米颗粒已经研究以克服这些困难。本综述提供了某些黄酮类和多酚类（岑雪芹，芸香素，白藜芦醇，槲皮素，水飞蓟素，儿茶素，黄酮，平静，没食子酸，芦丁和姜黄素）在结直肠癌模型中的有效性概述。它全面讨论了黄酮类纳米制剂在其生物功能中的影响，包括细胞摄取率、生物利用度、溶解度和细胞毒性，以及它们在体内情况下减少结直肠癌肿瘤大小的潜力 。版权所有 © 2023. Elsevier B.V. 发布。

Colorectal cancer is among the frequently diagnosed cancers with high mortality rates around the world. Polyphenolic compounds such as flavonoids are secondary plant metabolites which exhibit anti-cancer activities along with anti-inflammatory effects. However, due to their hydrophobicity, sensitivity to degradation and low bioavailability, therapeutic effects have shown poor therapeutic effect. Nano delivery systems such as nanoliposomes, nanomicelles, silica nanoparticles have been investigated to overcome these difficulties. This review provides a summary of the efficiency of certain flavonoids and polyphenols (apigenin, genistein, resveratrol, quercetin, silymarin, catechins, luteolin, fisetin, gallic acid, rutin, and curcumin) on colorectal cancer models. It comprehensively discusses the influence of nano-formulation of flavonoids on their biological functions, including cellular uptake rate, bioavailability, solubility, and cytotoxicity, as well as their potential for reducing colorectal cancer tumor size under in vivo situations.Copyright © 2023. Published by Elsevier B.V.