转移是乳腺癌患者死亡的主要原因。虽然平行多克隆播种已被证明对于器官特异性转移起到贡献作用，但在过去十年中，横向交叉转移播种（转移到转移扩散）也已经被证明是多个部位的远处转移模式。作为乳腺癌转移最常见的第一个目的地，骨骼已经被证明促进乳腺癌细胞的二次播种。在本文中，我们总结了骨骼是乳腺癌二次播种的转移站的临床和实验证据。我们还讨论了骨骼微环境在乳腺癌二次播种中的调节机制，重点关注干细胞调控，静止-增殖平衡调节，表观遗传重编程和癌细胞免疫逃逸等方面。此外，我们还强调了未来的研究方向和预防骨骼二次播种的策略。©2023年。作者。

Metastasis is responsible for the majority of deaths among breast cancer patients. Although parallel polyclonal seeding has been shown to contribute to organ-specific metastasis, in the past decade, horizontal cross-metastatic seeding (metastasis-to-metastasis spreading) has also been demonstrated as a pattern of distant metastasis to multiple sites. Bone, as the most frequent first destination of breast cancer metastasis, has been demonstrated to facilitate the secondary dissemination of breast cancer cells. In this review, we summarize the clinical and experimental evidence that bone is a transfer station for the secondary dissemination of breast cancer. We also discuss the regulatory mechanisms of the bone microenvironment in secondary seeding of breast cancer, focusing on stemness regulation, quiescence-proliferation equilibrium regulation, epigenetic reprogramming and immune escape of cancer cells. Furthermore, we highlight future research perspectives and strategies for preventing secondary dissemination from bone.© 2023. The Author(s).