运动在癌症预防和控制中的作用越来越受到认可，根据临床前研究提出，白细胞的动员在抗肿瘤效应中发挥着重要作用。因此，我们研究了10分钟急性运动如何改变新诊断乳腺癌患者的免疫细胞。在静息、运动后立即以及运动后30分钟采集血样，并利用9色流式细胞术对主要白细胞亚群进行表型表征。急性运动后总白细胞计数增加29％，CD8 + T细胞计数增加34％，CD19 + B细胞计数增加18％，CD56 + CD16 + NK细胞计数增加130％，CD14 + CD16 +单核细胞计数增加51％。CD45 +、CD8 +、CD19 +和CD56 + CD16 +细胞的动员与运动收缩压、心率百分比、预测最大心率、心率压力积和平均动脉压正相关。我们的研究表明，仅10分钟的急性运动就可以导致乳腺癌患者的白细胞增多。白细胞的动员似乎与运动强度直接相关。运动对肿瘤治疗效果的积极作用可能部分归因于免疫细胞动员，正如本研究所证实的。© 2023.作者（们）。

The role of exercise in cancer prevention and control is increasingly recognized, and based on preclinical studies, it is hypothesized that mobilization of leukocytes plays an important role in the anti-tumor effect. Thus, we examined how 10-min acute exercise modulates immune cells in newly diagnosed breast cancer patients. Blood samples were taken at rest, immediately after exercise and 30 min after exercise and phenotypic characterization of major leukocyte subsets was done using 9-color flow cytometry. Total leukocyte count increased by 29%, CD8+ T cell count by 34%, CD19+ B cell count by 18%, CD56+CD16+ NK cell count by 130%, and CD14+CD16+ monocyte count by 51% immediately after acute exercise. Mobilization of CD45+, CD8+, CD19+, and CD56+CD16+ cells correlated positively with exercising systolic blood pressure, heart rate percentage of age predicted maximal heart rate, rate pressure product, and mean arterial pressure. Our findings indicate that a single bout of acute exercise of only 10 min can cause leukocytosis in breast cancer patients. Mobilization of leukocytes appear to be directly related to the intensity of exercise. It is possible that the positive effect of exercise on oncologic outcome might be partly due to immune cell mobilization as documented in the present study.© 2023. The Author(s).