恶性肿瘤的外周和纤维化组织的前沿具有类似的代谢途径。两者都使用糖酵解作为主要能源来源，生产生物质并导致微环境的酸化。低pH已被证明能增加癌细胞在体外和体内破坏周围组织的能力。TGF-B的pH依赖性激活导致肌成纤维细胞的激活是纤维化启动和进展的重要步骤。在恶性肿瘤的外周和纤维化的前沿也报告了快速细胞增殖的标志物。了解这些疾病共同的分子和代谢特征可以解释患有纤维化的患者患癌症的增多。© 2023. The Author(s).

The periphery of malignant tumors and the leading edge of fibrotic tissue have analogous metabolic pathways. Both use glycolysis as the primary source of energy to produce biomass with consequential acidification of the microenvironment. A low PH has been shown to increase the ability of cancer cells to invade the surrounding tissue in both in vitro and in vivo studies. The pH-dependent activation of TGF-B leading to myofibroblast activation is an important step in the initiation and progression of fibrosis. Markers of accelerated cell proliferation have also been reported in the periphery of malignant tumors and the leading edge of fibrosis. Understanding the shared molecular and metabolic characteristics of these conditions may explain the increased prevalence of cancer among patients with fibrosis.© 2023. The Author(s).