原发性甲状旁腺功能亢进症（PHPT）是一种常见的内分泌失调，由于甲状旁腺肿瘤或增生引起，常伴有生活质量（QoL）受损。甲状旁腺切除术（PTX）是PHPT患者的首选标准治疗。在这项单中心研究中，我们旨在评估PHPT对患者QoL的影响，并在手术后的早期和长期随访中确定QoL的变化。所有患者均接受常规PTX，并切除疑似过度活跃的甲状旁腺（腺）组织。患者填写了通用的QoL调查问卷RAND SF-36、特定的PHPQoL问卷和特定的症状评估问卷PAS。在手术前入院时，手术后3个月、12个月和24个月，完成问卷调查。共纳入了92例PHPT患者（中位年龄为56岁，95.7%为女性）。在PTX手术前，患者的SF-36评分比健康对照组明显低（p＜0.01）。近40%的患者QoL较差或非常较差。PAS在手术前的最常见症状如下：疲劳（97.8%的患者）、虚弱（94.6%）、健忘（94.6%）、情绪变化（90%）、感到“沮丧”/抑郁（88%）、关节疼痛（83.3%）、头痛（80.2%）、持续烦躁（77.2%）、骨痛（75%）、口渴（70.7%）和起床困难（67.4%）。一半的患者具有中度到严重（≥ 40分）的疲劳、虚弱、关节疼痛、健忘以及情绪变化。在72名患者中分析了术后QoL变化。与手术前相比，手术后所有SF-36问卷的评分（除了身体疼痛）和PHPQoL总分显着改善（GEE，p＜0.01）。与基线值相比，疲劳、情绪变化、虚弱和健忘的严重程度在手术后显着减少（GEE，p＜0.05）。 PHPQoL的心理成分降低（OR=0.927，95% CI=0.874-0.984，p=0.013）可预测手术后QoL的改善。PHPT患者身体、心理和社交功能明显受损，并经历了一系列常见的PHPT症状。成功的PTX伴随着显着的QoL改善和术后至少24个月的主观症状减轻。 © 2023年作者（们）。

Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by a parathyroid tumor or hyperplasia, which is often accompanied with quality of life (QoL) impairment. A parathyroidectomy (PTX) is the preferred standard treatment for PHPT patients. In this single center study we aimed to evaluate the impact of PHPT on patient's QoL and identify QoL changes at early and long-term follow-up after surgery.All the patients underwent routine PTX with the removal of the suspected hyperparathyroid gland(s). Patients filled out generic QoL questionnaire RAND SF-36, specific questionnaire PHPQoL and specific symptom assessment questionnaire PAS upon admission to the hospital before surgery, at 3 months, 12 months and 24 months after surgery.A total of 92 patients with PHPT (median age was 56 years, 95.7% females) were included in the study. Before PTX patient's QoL by SF-36 scores was significantly lower as compared to healthy controls (p < 0.01). Almost 40% of patients had poor or very poor QoL. The most frequent symptoms by PAS before surgery were as follows: tiredness (97.8% of patients), weakness (94.6%), forgetfulness (94.6%), mood changes (90%), feeling "blue"/depression (88%), joint pains (83.3%), headaches (80.2%), constant irritability (77.2%), bone pains (75%), thirst (70.7%) and trouble getting out of a chair (67.4%). The half of the patients had moderate-to-severe (≥ 40 scores) tiredness, weakness, joint pains, forgetfulness, as well as mood changes. Post-operative QoL changes were analysed in the group of 72 patients. After surgery there was significant improvement in QoL by all scales of SF-36 questionnaire, excluding bodily pain, and the PHPQoL total score (GEE, p < 0.01) as compared with their values before surgery. Also severity of tiredness, mood changes, weakness and forgetfulness significantly decreased after surgery as compared to their baseline values (GEE, p < 0.05). Decreased mental component of QoL by PHPQoL (OR = 0.927, 95%CI = 0.874-0.984, p = 0.013) predicted improved QoL after surgery.Patients with PHPT demonstrated significantly impaired QoL in physical, psychological and social functioning as well experienced a wide profile of common PHPT symptoms. Successful PTX was accompanied with remarkable QoL improvement and decrease in subjective symptoms for at least 24 months after surgery.© 2023. The Author(s).