化疗引起的周围神经毒性（CIPN）是多种化疗药物常见的、剂量限制的、高成本的、难以治疗的不良反应，表现为远侧极端肢体的感觉和运动功能障碍。由于有效的治疗方法有限，CIPN 可以永久地降低患者的功能、独立性和生活质量。物理治疗中非常有前途的干预措施之一是包括运动、拉伸、平衡和手动治疗干预的物理治疗。目前，还没有 CIPN 的物理治疗指南，因此限制了其接受和潜在的有效性。我们利用作者在物理治疗、症状管理研究、肿瘤学、神经学和治疗 CIPN 患者方面的集体专业知识，提出了一种全面的物理治疗工作流程，以评估和治疗 CIPN。这个工作流程基于物理治疗治疗神经系统症状的指南、物理治疗和运动的临床研究结果以及物理治疗临床判断。我们提供了在临床设置中使用的相关物理治疗评估和治疗方法的详细表格。CIPN 评估应包括详细的感觉评估、受累肢体的客观力量评估以及包括静态和动态平衡、步态和功能活动能力在内的验证的体能表现度量。CIPN 的治疗应涉及到感觉运动、力量、平衡和耐力集中的干预，以及包括有氧训练的家庭锻炼处方。我们最终呼吁肿瘤学团队、物理治疗师、患者和研究人员采取行动项目，最好应用该框架来解决 CIPN。物理治疗师凭借其培训和普及的优势处于帮助评估、预防和治疗 CIPN 的独特位置，但目前还没有 CIPN 的物理治疗临床实践指南。我们的 CIPN 评估和治疗的初步建议可以催生评估和治疗 CIPN 的指南。我们敦促肿瘤学团队、物理治疗师、患者和研究人员制定、调整和传播这个框架，以帮助缓解癌症患者化疗的负担。 © 2023。作者，受 Springer-Verlag GmbH Germany、Springer Nature 的独家许可。

Chemotherapy-induced peripheral neurotoxicity (CIPN) is a highly prevalent, dose-limiting, costly, and tough-to-treat adverse effect of several chemotherapy agents, presenting as sensory and motor dysfunction in the distal extremities. Due to limited effective treatments, CIPN can permanently reduce patient function, independence, and quality of life. One of the most promising interventions for CIPN is physical therapy which includes exercise, stretching, balance, and manual therapy interventions. Currently, there are no physical therapy guidelines for CIPN, thus limiting its uptake and potential effectiveness.Utilizing the authors' collective expertise spanning physical therapy, symptom management research, oncology, neurology, and treating patients with CIPN, we propose a comprehensive clinical workflow for physical therapists to assess and treat CIPN. This workflow is based on (1) physical therapy guidelines for treating neurologic symptoms like those of CIPN, (2) results of clinical research on physical therapy and exercise, and (3) physical therapy clinical judgement.We present detailed tables of pertinent physical therapy assessment and treatment methods that can be used in clinical settings. CIPN assessment should include detailed sensory assessment, objective strength assessments of involved extremities, and validated physical performance measures incorporating static and dynamic balance, gait, and functional mobility components. CIPN treatment should involve sensorimotor, strength, balance, and endurance-focused interventions, alongside a home-based exercise prescription that includes aerobic training. We conclude with action items for oncology teams, physical therapists, patients, and researchers to best apply this framework to address CIPN.Physical therapists are in a unique position to help assess, prevent, and treat CIPN given their training and prevalence, yet there are no physical therapy clinical practice guidelines for CIPN. Our preliminary suggestions for CIPN assessments and treatments can catalyze the development of guidelines to assess and treat CIPN. We urge oncology teams, physical therapists, patients, and researchers to develop, adapt, and disseminate this framework to help alleviate the burden of chemotherapy on patients with cancer.© 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.