光疗法包括光热疗法（PTT）和光动力疗法（PDT），由于其非侵入性、高特异性和低副作用逐渐受到肿瘤治疗领域的关注。然而，在肿瘤微环境中，上调的热休克蛋白（HSPs）和反应性氧化物种（ROS）防御系统，如谷胱甘肽（GSH）或MutT同源物1（MTH1）蛋白，抵消了单一模式治疗（PTT或PDT）的有效性。因此，本文构建出高性能光热电催化效应的铋碲纳米片（Bi2 Te3 NPs），用于肿瘤协同治疗。在近红外光照射下，Bi2 Te3 NPs可诱导明显的PPT温度升高，并有效抑制MTH1表达。特别地，产生的热冷交替引起温度变化，产生电子-空穴分离以产生ROS，从而不仅损伤HSPs以减少热耐受性以增强PTT，而且还引起肿瘤细胞焦亡。此外，Bi2 Te3 NPs显著减少GSH，进一步提高ROS水平并降低谷胱甘肽过氧化物酶4（GPX4）的活性，从而引发肿瘤细胞铁死亡。由于光热电催化协同治疗，Bi2 Te3 NPs在体内和体外眼部肿瘤模型都具有令人印象深刻的肿瘤抑制作用。本研究为转化肿瘤微环境、提高光疗法治疗特异性的高性能多功能能量转化纳米平台提供了新思路。本文章受版权保护。版权所有，翻译仅供学习参考，不得用于任何商业用途。

Phototherapy including photothermal therapy (PTT) and photodynamic therapy (PDT) has gradually come into the limelight for oncological treatment due to its noninvasiveness, high specificity, and low side effects. However, upregulated heat-shock proteins (HSPs) and reactive oxygen species (ROS)-defensing system such as glutathione (GSH) or MutT homolog 1 (MTH1) protein in tumor microenvironment counteract the efficiency of single-modality therapy either PTT or PDT. Herein, the well-defined bismuth telluride nanoplates (Bi2 Te3 NPs) are engineered with a high-performance photo-thermo-electro-catalytic effect for tumor-synergistic treatment. Upon near-infrared light illumination, Bi2 Te3 NPs induce a significant temperature elevation for PTT, which effectively inhibits MTH1 expression. Especially, heating and cooling alteration caused temperature variations result in electron-hole separation for ROS generation, which not only damages HSPs to reduce the thermotolerance for enhance PTT, but also arouses tumor cell pyroptosis. Additionally, Bi2 Te3 NPs conspicuously reduce GSH, further improving ROS level and leading to decrease glutathione peroxidase 4 (GPX4) activity, which triggers tumor cell ferroptosis. Due to the photo-thermo-electro-catalytic synergistic therapy, Bi2 Te3 NPs are gifted with impressive tumor suppression on both ectopic and orthotopic ocular tumor models. This work highlights a high-performance multifunctional energy-conversion nanoplatform for reshaping tumor microenvironment to boost the tumor-therapeutic efficacy of phototherapy. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.