CDK7和FynB蛋白激酶由于在细胞功能（如细胞周期和神经信号转导）的调节作用等方面具有关键作用，因此已被认定为癌症和脑疾病治疗的相关靶点。几项研究表明，抑制这些蛋白质可能对改变这些疾病的发病或进展有益。通过生物测定引导的方法，对显示出有趣的激酶抑制活性的海绵Lendenfeldia chondrodes（Thorectidae）提取物进行了分馏。该研究导致了5个已知的1-5和一个新的6个多溴联苯醚（PBDEs）的分离。它们的结构鉴定是基于光谱数据（NMR和HRMS）和与文献数据的比较而建立的。

CDK7 and FynB protein kinases have been recognized as relevant targets for cancer and brain diseases treatment due to their pivotal regulatory roles in cellular functions such as cell cycle and neural signal transduction. Several studies demonstrated that the inhibition of these proteins could be useful in altering the onset or progression of these diseases. Based on bioassay-guided approach, the extract of the marine sponge Lendenfeldia chondrodes (Thorectidae), which exhibited interesting kinase inhibitory activities, was fractionated. The investigation led to the isolation of five known 1-5 and one new 6 polybrominated diphenyl ethers (PBDEs). Their structure elucidation was established based on spectroscopic data (NMR and HRMS) and comparison with literature data.