Biomodulina T（InmunyVital®）是一种调节免疫反应和炎症的胸腺因子。Biomodulina T刺激T细胞的分化、成熟和增殖。此外，Biomodulina T能提升T细胞产生细胞因子的能力，从而增强T淋巴细胞的功能。Biomodulina T刺激胸腺，因此促进胸腺发育不全儿童的胸腺恢复正常大小，并恢复老年人的免疫老化T细胞的功能。1984年，罗德里格斯·马丁·RR建立了生物调节剂实验室，他在其中创造和开发了一种免疫调节胸腺因子，他命名为“Biomodulina T”。 Biomodulina T的生物活性在数项研究中被证明。进行了广泛的临床前毒理学研究，并表明Biomodulina T是一种活性和安全的胸腺因子。Biomodulina T在免疫缺陷和感染、自身免疫疾病、老年人反复呼吸道感染和癌症患者中进行了临床试验。1994年，我们获得了Biomodulina T作为免疫调节药物的批准。本文识别了Biomodulina T发展中涉及的重要事件。自其发现以来超过35年，报告表明Biomodulina T是一种调节免疫反应和炎症非常有用的物质，可以恢复免疫系统在年轻人和老年人中的功能缺失和失衡，包括免疫缺陷、自身免疫疾病和感染。Biomodulina T还可作为一种免疫治疗剂，用于提高癌症和疫苗的免疫反应，逆转免疫老化以及改善老年人的健康状况。版权所有©2023 Elsevier B.V.。保留所有权利。

Biomodulina T (InmunyVital®) is a thymic factor that modulates immune response and inflammation. Biomodulina T stimulates the differentiation, maturation and proliferation of T cells. Additionally, Biomodulina T improves the ability of T cells to produce cytokines, therefore enhancing T lymphocyte function. Biomodulina T stimulates the thymus gland and, thus, promotes the recovery of normal thymus size in children with thymic hypoplasia and restores the functions of immunosenescent T cells in aging people. In 1984 Rodriguez Martin RR established the laboratory of Biomodulators, where he created and developed an immunomodulatory thymic factor that he named "Biomodulina T." The biological activity of Biomodulina T was demonstrated in several studies. An extensive series of preclinical toxicological studies were conducted and these studies demonstrated that Biomodulina T is an active and safe thymic factor. Clinical trials were conducted with Biomodulina T in patients with immunodeficiency and infections, autoimmune diseases, older adults with recurrent respiratory infections, and cancer. In 1994, we obtained the approval of Biomodulina T as an immunomodulatory drug. This article identifies the milestones involved in the development of Biomodulina T. Since its discovery more than 35 years ago, reports show that Biomodulina T is a modulator of immune response and inflammation that is very useful for restoring the immune system in young and elderly people with immunodeficiencies, autoimmune diseases, and infections. Biomodulina T is also useful as an immunotherapeutic agent for improving immune responses in cancer and vaccines, for reversing immunosenescence and for improving healthspan in aging.Copyright © 2023 Elsevier B.V. All rights reserved.