胰腺癌（PC）极具侵略性，预后极差。 PC的肿瘤微环境（TME）是复杂和异质的。微环境中的各种细胞组分能够分泌不同的活性物质，参与促进肿瘤的发展。它们的释放可能通过外泌体（即最丰富的细胞外囊泡（EVs）之一）发生，这些囊泡可以携带许多因子，并作为细胞间通讯的一种手段。新兴证据表明，miRNA参与调节和控制许多病理和生理过程。它们也可以通过外泌体从供体细胞转运到受体细胞，从而调节TME。外泌体miRNA在PC诊断和预后方面显示出很大的潜力，这可能揭示PC的新治疗策略。在本文中，我们回顾了外泌体miRNA在调节PC TME中的细胞相互作用中的重要作用，以及它们潜在的临床应用。版权所有©2023. Elsevier B.V.发表。

Pancreatic cancer (PC) is highly aggressive having an extremely poor prognosis. The tumor microenvironment (TME) of PC is complex and heterogeneous. Various cellular components in the microenvironment are capable of secreting different active substances that are involved in promoting tumor development. Their release may occur via exosomes, the most abundant extracellular vesicles (EVs), that can carry numerous factors as well as act as a mean of intercellular communication. Emerging evidence suggests that miRNAs are involved in the regulation and control of many pathological and physiological processes. They can also be transported by exosomes from donor cells to recipient cells, thereby regulating the TME. Exosomal miRNAs show promise for use as future targets for PC diagnosis and prognosis, which may reveal new treatment strategies for PC. In this paper, we review the important role of exosomal miRNAs in mediating cellular communication in the TME of PC as well as their potential use in clinical applications.Copyright © 2023. Published by Elsevier B.V.