[Anonymized for Review]试验比较了无法手术的早期非小细胞肺癌患者接受常规放疗（CRT）和立体定向放疗（SBRT）的效果。被随机分配接受SBRT治疗的患者的局部失败率较低，并且总生存率有所改善。这项分析报告了接受SBRT和CRT治疗的患者在肺功能测试（PFTs）和六分钟步行测试（SMWT）方面的差异。我们分析了所有招募到[匿名]试验的患者的PFT和SMWT。在这个试验期间，患者接受了连续的PFT。线性回归模型用于比较SBRT和CRT治疗后3个月和12个月之间的参数。共有101名患者入组，其中33名接受CRT治疗，61名接受SBRT治疗，7名未接受治疗。主要肿瘤大小在两组之间相似，SBRT为25毫米（标准差9毫米），CRT为28毫米（标准差9毫米）。回归分析表明，在治疗后3个月和12个月，两组之间在PFT下降或SMWT步行距离方面没有差异。CRT组的PTV大小显著大于SBRT组，分别为142.79 cc（标准差61.14cc）和46.15 cc（标准差23.39 cc）。目标所接收的平均生物等效剂量（BED）在SBRT组中显著大于CRT组，分别为125.92 Gy（标准差21.58 Gy）和65.49 Gy（6.32 Gy）。肺部的平均剂量-iGTV是CRT组的8.9 Gy（标准差2.34 Gy），SBRT组的为4.37 Gy（标准差1.42 Gy）。尽管SBRT给肿瘤提供了显著较高的生物学有效剂量，但两组之间观察到的呼吸功能下降没有差异。版权所有 © 2023 Elsevier Inc.发布。

The [Anonymized for Review] trial compared conventional radiotherapy (CRT) with stereotactic body radiation therapy (SBRT) in patients with inoperable early-stage non-small cell lung cancer. Patients randomised to SBRT had less local failure and improved overall survival. This analysis reports differences in pulmonary function tests (PFTs) and the six-minute walk test (SMWT) between patients who received SBRT and those who received CRT.We analyzed the PFTs and SMWT of all patients recruited to the [Anonymized for Review] trial. During this trial, patients underwent serial PFTs. Linear regression models were used to compare parameters between SBRT and CRT at 3 and 12-months post-treatment.101 patients were enrolled, 33 patients were treated with CRT, 61 with SBRT and 7 did not receive treatment. Primary tumor size was similar between arms, SBRT 25mm (SD 9mm) and CRT 28mm (SD 9mm). On regression analysis, at 3 and 12 months, there was no evidence of a difference between arms in PFT decline or distance walked in the SMWT. PTV size was significantly larger in the CRT arm, 142.79 cc (SD 61.14cc) compared to the SBRT group 46.15 cc (SD 23.39 cc). The mean Biological Equivalent Dose (BED) received by the target was significantly larger in the SBRT group 125.92 Gy (SD 21.58 Gy) compared to CRT 65.49 Gy (6.32Gy). Mean dose to the lungs - iGTV was 8.9 Gy (SD 2.34 Gy) in the CRT group and 4.37 Gy (SD 1.42 Gy) in the SBRT group.Despite the considerably higher biologically effective doses delivered to the tumor in SBRT, there was no difference in decline in respiratory function observed between the two groups.Copyright © 2023. Published by Elsevier Inc.