全球肥胖症的增加与多种人类癌症的发生和进展密切相关。这些关系在很大程度上是通过肥胖驱动的生理稳态破坏来介导的，这种破坏以局部和全身内分泌、炎症和代谢变化为特征。肥胖所导致的骨髓微环境（BMME）在多种癌症中起到了作用。越来越多的证据表明，肥胖背景下BMME的生理功能障碍，包括细胞组成、基质和免疫细胞功能以及能量代谢的改变，以及炎症和缺氧等因素，对癌症的发生和进展起到了贡献作用。然而，肥胖-BMME-癌症轴的机制仍然不清楚。在本综述中，我们讨论了了解肥胖期间BMME发展、其对癌症发生和进展的贡献以及对癌症治疗的影响的最新进展。版权所有©2023 Elsevier Inc.。保留所有权利。

Obesity is increasing globally and has been closely linked to the initiation and progression of multiple human cancers. These relationships, to a large degree, are mediated through obesity-driven disruption of physiological homeostasis characterized by local and systemic endocrinologic, inflammatory, and metabolic changes. Bone marrow microenvironment (BMME), which evolves during obesity, has been implicated in multiple types of cancer. Growing evidence shows that physiological dysfunction of BMME with altered cellular composition, stromal and immune cell function, and energy metabolism, as well as inflammation and hypoxia, in the context of obesity contributes to cancer initiation and progression. Nonetheless, the mechanisms underlying the obesity-BMME-cancer axis remain elusive. In this review, we discuss the recent advances in understanding the evolution of BMME during obesity, its contributions to cancer initiation and progression, and the implications for cancer therapy.Copyright © 2023 Elsevier Inc. All rights reserved.