一项比较研究,旨在研究两种不同的送药方式对下肢骨骼和软组织肉瘤患者的化疗药物治疗疗效的影响。
A comparative study between two methods of delivery of chemotherapeutic agent in patients with bone and soft tissue sarcoma of lower extremity.
发表日期:2023 Apr 22
作者:
Jing Shan, Sumei Lv, Haihong Li, Donglai Wang, Xiaoyu Zhang, Wei Liu
来源:
Bone & Joint Journal
摘要:
我们旨在比较在下肢恶性骨骼和软组织肿瘤患者中,经外周插管置入中心静脉插管(PICC)和埋置型静脉通路装置(TIVAD)的并发症和肩功能方面的影响。我们在河北医科大学第四医院骨科部门从2019年6月至2021年12月期间,分析了65例TIVAD(胸壁)和65例PICC的病例,这些患者被诊断出患有下肢恶性骨肿瘤或软组织肿瘤(肿瘤需对化疗相对敏感),接受规律化疗,达到14个疗程以上(42周)。这两组在导管滞留时间、导管相关并发症、Constant-Murley肩关节功能评分和导管端位于导管性痛侧位置的错位方面进行了比较。与PICC组相比,在导管置入后6个月,TIVAD组报告了更好的导管滞留时间、导管相关并发症和导管性痛侧肩关节的Constant-Murley得分的结果(p <0.05)。TIVAD组的导管性痛侧肩关节的导管端错位也较少(P<0.05)。与PICC相比,TIVAD可以延长导管的滞留时间,减少导管相关并发症和保持肩关节功能,这使得它成为提供下肢恶性骨骼和软组织肿瘤患者化疗的理想静脉通路途径。©2023。作者。
We aimed to compare the effects of peripherally inserted central catheters (PICC) and implantable venous access devices (TIVADs) in terms of complications and shoulder function in patients with malignant bone and soft tissue tumors of the lower extremities.We analyzed 65 cases of TIVADs (chest wall) and 65 cases of PICC at the orthopedic department of the Fourth Hospital of Hebei Medical University between June 2019 and December 2021, which were diagnosed with malignant bone tumors or soft tissue tumors of the lower extremities (tumors had to be relatively sensitive to chemotherapy), received regular chemotherapy, with ≥ 14 cycles (42 weeks). The two groups were compared in terms of catheter indwelling time, catheter-related complications, Constant-Murley shoulder function score, and displacement of the position of the catheter end on the catheterization side.Compared to the PICC group, at six months after catheterization, the TIVADs group reported better outcomes for catheter indwelling time, catheter-related complications, and Constant-Murley score for the catheterization-side shoulder joint (p < 0.05). The TIVADs group also reported less displacement of the catheter end position after 180° abduction of the catheterization-side shoulder joint (p < 0.05).Compared with PICC, TIVADs can prolong catheter indwelling time, reduce catheter-related complications, and maintain shoulder joint function, which makes it an ideal venous-access approach when providing chemotherapy to patients with malignant bone and soft tissue tumors of the lower extremities.© 2023. The Author(s).