多细胞生物的发育取决于细胞粘附分子（CAM），它们连接细胞以构建组织。免疫球蛋白超家族（IgSF）构成了CAM中最大的家族之一。该家族的成员调节诸如突触形成、精子发生、白细胞-内皮相互作用或上皮细胞-细胞黏附等多种过程。它们通过它们的细胞外区域在顺式和反式上经历同源和异源相互作用。它们的胞浆区域经常结合支架蛋白以组装信号复合物。跨膜和免疫球蛋白域含1（TMIGD1）是一种具有两个Ig样结构域和一个含有PDZ结合基序的短胞浆尾巴的IgSF成员。最近的观察表明TMIGD1在上皮细胞中具有多种功能，并且在抑制恶性细胞行为中起着关键作用。在这里，我们回顾了TMIGD1的分子特征、其与胞浆支架蛋白的相互作用、其表达的调节以及它在结肠直肠癌和肾癌中的下调。©2023年。作者（S）。

The development of multicellular organisms depends on cell adhesion molecules (CAMs) that connect cells to build tissues. The immunoglobulin superfamily (IgSF) constitutes one of the largest families of CAMs. Members of this family regulate such diverse processes like synapse formation, spermatogenesis, leukocyte-endothelial interactions, or epithelial cell-cell adhesion. Through their extracellular domains, they undergo homophilic and heterophilic interactions in cis and trans. Their cytoplasmic domains frequently bind scaffolding proteins to assemble signaling complexes. Transmembrane and immunoglobulin domain-containing protein 1 (TMIGD1) is a IgSF member with two Ig-like domains and a short cytoplasmic tail that contains a PDZ domain-binding motif. Recent observations indicate that TMIGD1 has pleiotropic functions in epithelial cells and has a critical role in suppressing malignant cell behavior. Here, we review the molecular characteristics of TMIGD1, its interaction with cytoplasmic scaffolding proteins, the regulation of its expression, and its downregulation in colorectal and renal cancers.© 2023. The Author(s).