研究动态
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微小RNA在癌症发生中的作用以及微小RNA检测在胃癌发展诊断中的实用性。

The role of microRNAs in carcinogenesis and the utility of microRNA determination in diagnosis of gastric cancer development.

发表日期:2022 Dec
作者: G Cholewinski, M Waluga
来源: MOLECULAR & CELLULAR PROTEOMICS

摘要:

胃癌(GC)是全球最常见的恶性肿瘤之一,也是六种最常见的导致癌症相关死亡的原因之一。GC是一种多因素疾病,环境因素和遗传因素都可能影响其发生和发展。本文旨在研究ncRNA对胃癌发展的影响。我们查阅了医学数据库,探讨了不同micro RNA片段与胃癌发展之间的可能关系。结果显示,在过去的十年中,越来越多的包括miRNA和lncRNA在内的ncRNA被证明对胃癌有影响。这些ncRNA在胃癌组织中异常表达,发挥着在胃癌发生和发展中的关键作用,并且它们的评估在胃癌的诊断、预后或治疗方面具有潜在的益处。虽然许多ncRNA的异常表达在促进胃癌的作用已被描述,但有关这些ncRNA在胃癌发生机制中的作用的基础分子机制尚不明确。在本文中,讨论了与胃癌相关的一些miRNA。
Gastric cancer (GC) is one of the most prevalent malignancies worldwide and the six most common cause of cancer-related deaths. GC is a multifactorial disease in which both environmental and genetic factors can influence its occurrence and development. The aim of this paper is to investigate the effect of ncRNAs on the development of gastric cancer. We have reviewed medical databases on the possible relationship between different micro RNA fragments and the development of gastric cancer. In result, our review of medical databases indicated that over the past decade, an increasing number of ncRNAs, including miRNAs and lncRNAs, have been documented to affect gastric cancer. These ncRNAs are abnormally expressed in gastric cancer tissues, play key roles in gastric carcinogenesis and their assessment have potential benefits in the diagnosis, prognosis or treatment of gastric cancer. Although the role of abnormal expression of many ncRNAs in stimulating gastric cancer has been described, the underlying molecular mechanisms regarding the function of these ncRNAs in gastric carcinogenesis are not well understood. In the article, some of the miRNAs associated with gastric cancer are discussed.