本研究的目的是确定肌肉量在小儿脑肿瘤患者中是否可通过肌肉量评估指数（SI）来测量。我们回顾性地收集了1-16岁患者的血清肌酐（Cr）和半胱氨酸C（CysC）的水平，并在腰部椎体3-4的磁共振成像扫描中评估了总腰肌面积（tPMA）。变量使用与年龄和性别相关的参考标准计算的z分数进行比较。我们假设低SI表示较少的骨骼肌，因此可能表示脂肪过多。SI的z分数与tPMA的z分数（r = 0.004）无相关性。Cr和CysC水平的z分数与tPMA有正相关性（r = 0.249和0.320）。tPMA与z分数的BMI之间强烈相关（r = 0.582）。tPMA，Cr和CysC的z分数随着肿瘤WHO分级的增加而降低，但SI的z分数与WHO分级无显着的相关性。在我们的小儿脑肿瘤患者样本中，SI与肌肉量的相关性非常弱。它作为脂肪过多的生物标志物的可靠性需要更多的研究。© 2023年美国肠外肠内营养学会。

The aim of this study is to determine whether the sarcopenia index (SI) is a viable measure of muscle mass in pediatric patients with brain tumors.Retrospectively enrolled patients (1-16 years) who had serum creatinine (Cr) and cystatin C (CysC) levels evaluated within 28 days of an abdomen magnetic resonance imaging scan for the lumbar vertebrae 3-4 total psoas muscle area (tPMA) were studied. Variables were compared using their z scores calculated from age- and sex-dependent reference. We hypothesized that a low SI indicated less skeletal muscle, and therefore potentially indicated sarcopenia.The SI z score had no correlation with tPMA z score (r = 0.004). Both Cr and CysC levels were positively correlated with tPMA in z scores (r = 0.249 and 0.320). tPMA strongly correlated with body mass index in z scores (r = 0.582). The z scores of tPMA, Cr and CysC decreased with elevated World Health Organization grades of tumor, but the z scores of SI showed no significant dependence on WHO grades.The correlation of SI to muscle mass is very weak in our sample of pediatric patients with brain tumor. Its viability as biomarker for sarcopenia needs more study.© 2023 American Society for Parenteral and Enteral Nutrition.