患有慢性胰腺炎（CP）的患者常常出现剧烈和棘手的腹痛，导致生活质量（QOL）下降、无法工作或上学，由于多次急诊访问和住院而增加了医疗保健费用。我们在日本的中心评估了全胰腺切除和胰岛自体移植术（TPIAT）在CP患者疼痛控制和QOL方面的疗效。为评估QOL，我们使用了短形式36健康调查问卷第2版（SF-36v2®标准，日文版）、欧洲研究与治疗癌症组织的生命质量问卷核心30（EORTC QLQ-C30）和胰腺修饰生命质量问卷（QLQ-PAN28）。我们在2016年8月至2019年6月期间在5名患者中进行了此项手术。所有患者均接受了12个月的随访，所有移植的胰岛在1年的随访中仍然有效。主要的不良事件包括腹壁出血、肠梗阻、腹腔脓肿和需要住院治疗的腹痛；没有任何一例有后遗症。没有主要并发症是由于胰岛移植导致的。所有患者术后疼痛评分均有所改善。在12个月的TPIAT后，SF-36的三项QOL维度职业身体（p = 0.03125）、一般健康感知（p = 0.03125）和生命力（p = 0.03125）均有显着改善。许多其他QOL项目的平均值有所改善，但没有显着差异。CP的TPIAT治疗后QOL改善表明其在日本人群中的有效性。

Patients with chronic pancreatitis (CP) often have severe and intractable abdominal pain, leading to decreased quality of life (QOL), inability to work or attend school, and increased health care costs due to repeated emergency room visits and hospitalizations.We evaluated the efficacy of total pancreatectomy and islet autotransplantation (TPIAT) in terms of pain control and QOL in CP patients treated at our center in Japan. To evaluate QOL, we used the Short-Form 36 Health Survey version 2 (SF-36v2® Standard, Japanese), European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), and Quality of Life Questionnaire-Pancreatic Modification (QLQ-PAN28).Between August 2016 and June 2019, we performed this procedure in 5 patients. All patients were followed up for 12 months and all transplanted islets were still functioning at the 1-year follow-up. The major adverse events were abdominal wall hemorrhage, intestinal obstruction, intra-abdominal abscess, and abdominal pain requiring hospitalization; no case had sequelae. No major complications were due to islet transplantation. Pain scores improved postoperatively in all patients. Three QOL item dimensions role-physical (p = 0.03125), general health perception (p = 0.03125) and vitality (p = 0.03125) in the SF-36 were significantly improved 12 months after TPIAT. Mean values of many other QOL items improved, though not significantly.The QOL improvement after TPIAT for CP suggests its effectiveness in the Japanese population.