先天免疫在感染期间以及应对压力条件下的稳态作用中都发挥着重要作用。免疫系统的激活包括先天免疫反应在肿瘤发生和发展的初始化和进展中具有关键作用。先天免疫传感器识别病原体相关分子模式（PAMPs），激活环状GMP-AMP合成酶（cGAS）-干扰素基因刺激剂（STING）（cGAS-STING）并在病毒和细菌感染期间引发1型免疫反应。在细胞衰老和DNA损伤等状态下，正常细胞和肿瘤细胞对cGAS-STING的调节方式不同，与来自不同起源的肿瘤的进展有关。cGAS与细胞质dsDNA结合并合成环状GMP-AMP（2'3'-cGAMP），其选择性激活STING和下游IFN和NF-κB激活。我们在此回顾了cGAS-STING信号通路及其与其他通路的交互作用以调节肿瘤发生。此外，该综述还专注于针对cGAS-STING通路开发靶向治疗和癌症不同起源的组合方案的新兴研究。版权所有 ©2023 Elsevier B.V.发行。

Innate immunity plays an important role not only during infection but also homeostatic role during stress conditions. Activation of the immune system including innate immune response plays a critical role in the initiation and progression of tumorigenesis. The innate immune sensor recognizes pathogen-associated molecular patterns (PAMPs) and activates cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) (cGAS-STING) and induces type-1 immune response during viral and bacterial infection. cGAS-STING is regulated differently in conditions like cellular senescence and DNA damage in normal and tumor cells and is implicated in the progression of tumors from different origins. cGAS binds to cytoplasmic dsDNA and synthesize cyclic GMP-AMP (2'3'-cGAMP), which selectively activates STING and downstream IFN and NF-κB activation. We here reviewed the cGAS-STING signalling pathway and its cross-talk with other pathways to modulate tumorigenesis. Further, the review also focused on emerging studies that targeted the cGAS-STING pathway for developing targeted therapeutics and combinatorial regimens for cancer of different origins.Copyright © 2023. Published by Elsevier B.V.