胰岛素样生长因子结合蛋白（IGFBPs）是胰岛素样生长因子生物活性的重要调节因子。IGFBP家族在不同类型的癌症中发挥不同的作用，我们目前仍缺乏全面和全能的理解。从癌症基因组图谱（TCGA）、Oncomine、癌细胞系百科全书（CCLE）和人类蛋白质图谱（HPA）中提取的多源多维度数据用R语言进行生物信息学分析。免疫组化和qRT-PCR用于验证数据库分析结果。文献计量学和文献综述用于总结IGFBP在肿瘤领域的研究进展。IGFBP基因家族的成员在各种癌症类型中表达差异。IGFBP的表达可以影响不同癌症的预后。IGFBP的表达与多种信号转导途径相关。IGFBP的表达与肿瘤突变负荷、微卫星不稳定性、肿瘤干细胞性和肿瘤免疫微环境显著相关。qRT-PCR实验证实，胃癌中IGFBP2和IGFBP6的表达较低，结直肠癌中IGFBP6的表达较低。免疫组化验证了胃癌组织中IGFBP2蛋白的明显下调。IGFBP相关出版物的关键词共现分析显示，相对研究更集中于IGFBP作为肿瘤诊断和预后标志物以及开发癌症治疗的潜力。这些发现为IGFBP相关研究的前沿趋势提供了新线索，为确定各种癌症的新型治疗靶点提供了新的线索。©2023年作者。

Insulin-like growth factor binding proteins (IGFBPs) are critical regulators of the biological activities of insulin-like growth factors. The IGFBP family plays diverse roles in different types of cancer, which we still lack comprehensive and pleiotropic understandings so far.Multi-source and multi-dimensional data, extracted from The Cancer Genome Atlas (TCGA), Oncomine, Cancer Cell Line Encyclopedia (CCLE), and the Human Protein Atlas (HPA) was used for bioinformatics analysis by R language. Immunohistochemistry and qRT-PCR were performed to validate the results of the database analysis results. Bibliometrics and literature review were used for summarizing the research progress of IGFBPs in the field of tumor.The members of IGFBP gene family are differentially expressed in various cancer types. IGFBPs expression can affect prognosis of different cancers. The expression of IGFBPs expression is associated with multiple signal transduction pathways. The expression of IGFBPs is significantly correlated with tumor mutational burden, microsatellite instability, tumor stemness and tumor immune microenvironment. The qRT-PCR experiments verified the lower expression of IGFBP2 and IGFBP6 in gastric cancer and the lower expression of IGFBP6 in colorectal cancer. Immunohistochemistry validated a marked downregulation of IGFBP2 protein in gastric cancer tissues. The keywords co-occurrence analysis of IGFBP related publications in cancer showed relative research have been more concentrating on the potential of IGFBPs as tumor diagnostic and prognostic markers and developing cancer therapies.These findings provide frontier trend of IGFBPs related research and new clues for identifying novel therapeutic targets for various cancers.© 2023. The Author(s).