以前关于生活方式干预对结直肠癌（CRC）幸存者生活质量（QoL）影响的研究结果存在争议，近年来该领域有几篇新文献出现。为了评估生活方式干预能否促成CRC幸存者的有利健康结局和改善QoL，我们进行了一项荟萃分析。我们系统地搜索了PubMed、EMBASE、Web of Science和Cochrane Library，以获取1990年1月1日至2021年11月1日发表的相关文献。数据被要求从中提取并汇总，以比较生活方式干预和常规护理之间的身体活动水平、QoL、心理健康评估和人类测量数据。共纳入了12项研究。与对照组相比，生活方式干预可以显著增加身体活动时间（加权均差[WMD]，9.84；95%置信区间[CI]，1.20-18.48；P = .026）、代谢当量值水平（WMD，10.40；95% CI, 5.30-15.49；P < .001）和癌症治疗功能评估量表-结直肠得分（WMD，3.12；95% CI，0.24-5.99；P = .034）。但是，生活方式干预并未着重改善CRC幸存者的疲劳、抑郁水平、焦虑水平、腰围或身体质量指数。生活方式干预能促成CRC幸存者身体活动时间、代谢当量值和QoL的增加。未来需要包括身体活动、饮食或综合计划的生活方式干预，以提高CRC幸存者的身体活动水平并改善其QoL。版权所有©2023 Wolters Kluwer Health，Inc.

The results of previous studies on the effects of lifestyle interventions on the quality of life (QoL) in colorectal cancer (CRC) survivors remain controversial, and there have been several new publications in this area in recent years.To assess whether lifestyle interventions can lead to favorable health outcomes and improved QoL in CRC survivors, we performed a meta-analysis.PubMed, EMBASE, Web of Science, and Cochrane Library were systematically searched to obtain relevant literature published from January 1, 1990, to November 1, 2021. The required data were extracted and summarized to compare the physical activity levels, QoL, mental health assessment, and anthropometric data between lifestyle interventions and routine nursing.Twelve studies were included. Compared with the control group, lifestyle interventions could significantly increase the physical activity time (weighted mean difference [WMD], 9.84; 95% confidence interval [CI], 1.20-18.48; P = .026), metabolic equivalent task levels (WMD, 10.40; 95% CI, 5.30-15.49; P < .001), and Functional Assessment of Cancer Therapy Scale-Colorectal scores (WMD, 3.12; 95% CI, 0.24-5.99; P = .034). However, lifestyle interventions were not noticeably able to improve the fatigue, depression levels, anxiety levels, waist circumference, or body mass index in CRC survivors.Lifestyle interventions could generate an increase in physical activity time, metabolic equivalent task levels, and QoL in CRC survivors.Lifestyle interventions in the future that include physical activity, diet, or comprehensive programs are needed to increase physical activity levels and improve QoL in CRC survivors.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.