白细胞介素27（IL-27）是一个多效性细胞因子，参与调节机体的先天性和获得性免疫。先前的研究表明，在体内，IL-27介导多种炎症反应。随着动物模型和技术工具的发展，一些研究表明，它也与自身免疫性疾病和其他免疫相关疾病密切相关，并被认为是治疗病毒病、自身免疫性疾病、肿瘤和肥胖症的重要候选药物。因此，本文回顾了IL-27在获得性免疫缺陷综合症（AIDS）、类风湿性关节炎、肿瘤和肥胖症中的作用的最新进展，并旨在为治疗免疫相关疾病提供新思路。

Interleukin 27 (IL-27) is a pleiotropic cytokine that is involved in the regulation of the body's innate and adaptive immunity. Previous studies have shown that IL-27 mediates a variety of inflammatory responses in vivo. With the development of animal models and technical tools, several studies have shown that it is also closely associated with autoimmune diseases and other immune related diseases, and is considered as an important candidate for the treatment of viral disease, autoimmune diseases, tumors and obesity. Therefore, this paper reviews recent progress on the role of IL-27 in acquired immunodeficiency syndrome (AIDS), rheumatoid arthritis, tumors and obesity, with the aim of providing new ideas for the treatment of immune related diseases.