由于症状和临床表现相似，诊断和治疗口腔病变对于大多数临床医生来说都是一项具有挑战性的任务。组织病理学和免疫组织化学常常有助于诊断。本研究的目的是描述口腔黏膜病变患者的临床特征、组织病理学特征和系统整体联系。在三级医疗保健中心进行了一项横断面描述性研究，包括369例口腔黏膜病变的病例。男性占病例的61.78%。32.25%的病例有烟草、槟榔咀嚼、吸烟和饮酒史，29.81%、26.56%和11.38%的病例分别有槟榔咀嚼、口吸和饮酒史。常见症状是疼痛、灼烧感、口腔疼痛和溃疡。17.89%的病例口腔和皮肤都有受累。口腔扁平苔藓（口LP）是患者最多的组（21.96%），其中网格型是最常见的类型，颊粘膜是最常见的部位。口腔癌占20.33%的病例，感染性病因占11.92%，囊状水疱性疾病组（10.30%），口疮性口炎占8.94%，癌前病变占7.05%，如白斑（3.80%）和黏膜下纤维化（2.44%）。209例进行了组织病理学检查。口LP（90.27%）、口疱疹样脓疱病（82.35%）和恶性肿瘤（98.66%）中存在临床病理学相关。口LP是病例最多的组，其次是口腔鳞状细胞癌（SCC）。还有一些罕见的情况，如Melkersson-Rosenthal综合征和蓝色橡皮泡痣综合征，也是研究的一部分。在这个多样化的疾病群体中进行彻底的临床和病理学检查可以确定诊断。版权所有：©2023年《印度皮肤科在线期刊》。

Diagnosing and treating oral cavity lesions is a challenging task for most of the clinicians due to similar symptoms and clinical appearances. Frequently, histopathology and immunohistochemistry aid in making the diagnosis.The objectives were to describe the clinical features, and histopathological features and systemic association in patients with oral mucosal lesions (OML).A cross-sectional descriptive study was undertaken at a tertiary care centre in patients with OML. A total of 369 cases with OML were included in the study.Males constituted 61.78% of the cases. History of habits such as tobacco, gutka chewing, smoking, and alcohol was given by 32.25%, 29.81%, 26.56%, and 11.38% of cases, respectively. Common symptoms were soreness, burning sensation, oral pain and ulcers. Both oral and cutaneous involvement was seen in 17.89% of cases. Oral lichen planus (oral LP) constituted largest group of patients (21.96%) wherein reticulate type was the most frequent type and buccal mucosa was the commonest site. Oral carcinomas constituted 20.33% of cases followed by infective etiology (11.92%), vesiculobullous group of diseases (10.30%), aphthous stomatitis (8.94%), premalignant lesions (7.05%) such as leukoplakia (3.80%) and submucous fibrosis (2.44%). Histopathology was done in 209 cases. Clinico-histopathological correlation was seen in oral LP (90.27%), oral pemphigus (82.35%), and malignancies (98.66%).Oral LP formed the largest group of cases followed by Oral squamous cell carcinoma (SCC). Several rare conditions, such as Melkersson-Rosenthal syndrome and blue rubber bleb nevus syndrome were also a part of the study. Thorough clinical and histopathological examination in this diverse group of diseases clinches the diagnosis.Copyright: © 2023 Indian Dermatology Online Journal.