精胺是一种天然存在的多胺化合物，存在于精液中。它也存在于几种植物源中，并且具有显著的生物学特征，尤其是其抗癌特性。精胺特异地干扰肿瘤细胞周期，导致肿瘤细胞增殖的抑制和肿瘤生长的抑制。此外，它还通过调节关键的肿瘤学途径触发自噬作用。增加多胺，如精胺的摄入，可以通过其对抗癌免疫监视和多胺代谢调节的作用，抑制癌变并减缓肿瘤生长。精胺/精胺N-1乙酰转移酶（SSAT）在多胺稳态中起着关键作用，并在人类癌症中作为诊断标志物。精胺的化学修饰衍生物在预后、诊断和治疗多种恶性肿瘤的应用方面具有很大的潜力。本文详细讨论了最近发现的支持精胺和其分子生理机制抗癌的机制。版权所有 © 2023 Prasher，Sharma，Singh，Gulati，Chellappan，Rajput，Gupta，Ydyrys，Kulbayeva，Abdull Razis，Modu，Sharifi-Rad和Dua。

Spermidine is a naturally occurring polyamine compound found in semen. It is also found in several plant sources and boasts a remarkable biological profile, particularly with regards to its anticancer properties. Spermidine specifically interferes with the tumour cell cycle, resulting in the inhibition of tumor cell proliferation and suppression of tumor growth. Moreover, it also triggers autophagy by regulating key oncologic pathways. The increased intake of polyamines, such as spermidine, can suppress oncogenesis and slow the growth of tumors due to its role in anticancer immunosurveillance and regulation of polyamine metabolism. Spermidine/spermine N-1-acetyltransferase (SSAT) plays a critical role in polyamine homeostasis and serves as a diagnostic marker in human cancers. Chemically modified derivatives of spermidine hold great potential for prognostic, diagnostic, and therapeutic applications against various malignancies. This review discusses in detail the recent findings that support the anticancer mechanisms of spermidine and its molecular physiology.Copyright © 2023 Prasher, Sharma, Singh, Gulati, Chellappan, Rajput, Gupta, Ydyrys, Kulbayeva, Abdull Razis, Modu, Sharifi-Rad and Dua.