肥胖和2型糖尿病（T2D）是慢性病，对个体的整体健康有不良影响。目前，使用药物治疗肥胖和T2D的效果有限，并具有副作用。因此有必要研究更安全、成本更低廉、却同样有效的治疗方法，以缓解肥胖和T2D的继发并发症。植物性治疗方案因其卓越的特性和安全性正在受到越来越多的关注。我们在PubMed、Scopus、Google和Semantic scholar上搜索了自发布以来到2023年的Corchorus olitorius（C. olitorius）在肥胖和T2D方面的临床前证据。我们的焦点是了解这种植物性治疗方案对基本的血糖、脂质、炎症和氧化应激生物标志物的有益影响。这篇综述所收集的证据表明，在肥胖和T2D的啮齿动物模型中，C. olitorius的治疗可以显著减少血糖、体重、总胆固醇、甘油三酯和低密度脂蛋白（LDL），同时增加高密度脂蛋白胆固醇（HDL-c）。有趣的是，这一效应与马来醛、超氧化物歧化酶和催化剂减少、肿瘤坏死因子-α、白细胞介素和瘦素的减少一致。C. olitorius降低血糖的一些机制是通过刺激胰岛素分泌、增加β细胞增殖，从而促进胰岛素敏感性；该过程由植物中存在的抗坏血酸介导。C. olitorius的抗高血脂作用归因于该植物中的酚酸含量，它抑制3-羟基-3-甲基谷氨酰辅酶A（HMG-CoA）还原酶抑制剂，从而导致胆固醇合成减少和肝脏LDL-c受体表达增加。本文综述提供了广泛的知识，并进一步凸显了C. olitorius在肥胖和T2D啮齿动物模型中对基本代谢参数、脂质谱、炎症和氧化应激的潜在好处。版权所有 © 2023 Mokgalaboni和Phoswa。

Obesity and type 2 diabetes (T2D) are chronic conditions with detrimental impacts on the overall health of individuals. Presently, the use of pharmacological agents in obesity and T2D offers limited benefits and pose side effects. This warrant studies on remedies that are less toxic and inexpensive while effective in ameliorating secondary complications in obesity and T2D. Plant-based remedies have been explored increasingly due to their remarkable properties and safety profile. We searched for pre-clinical evidence published from inception until 2023 on PubMed, Scopus, Google, and Semantic scholar on Corchorus olitorius (C. olitorius) in both obesity and T2D. Our focus was to understand the beneficial impact of this plant-based remedy on basic glycemic, lipid, inflammatory, and biomarkers of oxidative stress. The evidence gathered in this review suggests that C. olitorius treatment may significantly reduce blood glucose, body weight, total cholesterol, triglycerides, and low-density lipoprotein (LDL) in concomitant with increasing high-density lipoprotein-cholesterol (HDL-c) in rodent models of obesity and T2D. Interestingly, this effect was consistent with the reduction of malonaldehyde, superoxide dismutase and catalases, tumor necrosis factor-alpha, interleukins, and leptin. Some of the mechanisms by which C. olitorius reduces blood glucose levels is through stimulation of insulin secretion, increasing β-cell proliferation, thus promoting insulin sensitivity; the process which is mediated by ascorbic acid present in this plant. C. olitorius anti-hyperlipidemia is attributable to the content of ferulic acid found in this plant, which inhibits 3-Hydroxy-3-methyl glutaryl coenzyme A (HMG-CoA) reductase inhibitors and thus results in reduced synthesis of cholesterol and increased hepatic LDL-c receptor expression, respectively. The present review provides extensive knowledge and further highlights the potential benefits of C. olitorius on basic metabolic parameters, lipid profile, inflammation, and oxidative stress in rodent models of obesity and T2D.Copyright © 2023 Mokgalaboni and Phoswa.