神经母细胞瘤 (NB) 是儿童中最常见的实性恶性肿瘤，占儿童癌症死亡率的15％。非编码 RNA 在 NB 发病机制中非常重要。作为一种新近发现的非编码 RNA，circRNA 的异常调控（异常上调或下调）与多种肿瘤的发生机制有关，包括 NB。circRNA 主要通过微小 RNA 占位抑制调控 miRNA 靶基因的表达。 临床证据表明，某些 circRNA 的表达与 NB 的预后和临床特征相关，因此可能被利用为生物标志物或治疗靶点。本综述讨论了已经被证明在 NB 中发挥作用的 circRNA。版权所有© 2023 Wu、Tan 和 Yang。

Neuroblastoma (NB) is children's most prevalent solid malignant tumor, accounting for 15% of childhood cancer mortality. Non-coding RNA is important in NB pathogenesis. As a newly identified non-coding RNA, abnormal regulation (abnormal up-regulation or down-regulation) of the circRNAs expression is implicated in the tumorigenesis of various tumors, including NB. CircRNAs primarily regulate the expression of microRNA (miRNA) target genes by microRNA (miRNA) sponge adsorption. Clinical evidence suggests that the expression of certain circRNAs is associated with the prognosis and clinical features of NB and hence may be exploited as a biomarker or therapeutic target. This review examines circRNAs that have been demonstrated to play a function in NB.Copyright © 2023 Wu, Tan and Yang.