近年来，由于其独特的结构特性和有前途的生物相容性，Cu-BTC框架作为药物载体候选用于癌症治疗引起了相当大的关注。然而，其内在的医学成像不足可能限制其生物应用；为了解决这一问题，成功地将Fe3O4纳米颗粒作为成像剂引入多孔同构MOF[Cu3（BTC）2]作为药物载体，制备出一种磁性纳米/微米尺度MOF。合成的磁性MOFs对模型抗癌药物DOX表现出高负载能力（40.5%）和优异的pH响应药物释放性能。所提出的纳米复合材料不仅具有大的比表面积、高的磁响应、大的介孔体积、高的横向弛豫度（r2）和良好的稳定性，还表现出优异的生物相容性、特异性肿瘤细胞摄取和显著的癌细胞生存率抑制作用，而不需要任何靶向剂。预计这种合成的磁性纳米/微米复合材料可以用于临床用途，也可以作为光敏抗菌疗法以及pH/GSH/光三重响应纳米载体的平台。版权所有©2023 Gharehdaghi、Naghib、Rahimi、Bakhshi、Kefayat、Shamaeizadeh和Molaabasi。

Cu-BTC framework has received a considerable attention in recent years as a drug carrier candidate for cancer treatment due to its unique structural properties and promising biocompatibility. However, its intrinsic deficiency for medical imaging potentially limits its bioapplications; To address this subject, a magnetic nano/microscale MOF has been successfully fabricated by introducing Fe3O4 nanoparticles as an imaging agent into the porous isoreticular MOF [Cu3(BTC)2] as a drug carrier. The synthesized magnetic MOFs exhibits a high loading capacity (40.5%) toward the model anticancer DOX with an excellent pH-responsive drug release. The proposed nanocomposite not only possesses large surface area, high magnetic response, large mesopore volume, high transverse relaxivity (r 2) and good stability but also exhibits superior biocompatibility, specific tumor cellular uptake, and significant cancer cell viability inhibitory effect without any targeting agent. It is expected that the synthesized magnetic nano/microcomposite may be used for clinical purposes and can also serve as a platform for photoactive antibacterial therapy ae well as pH/GSH/photo-triple-responsive nanocarrier.Copyright © 2023 Gharehdaghi, Naghib, Rahimi, Bakhshi, Kefayat, shamaeizadeh and Molaabasi.