蛋氨酸回收途径负责将含硫代谢物回收至蛋氨酸。这个回收途径发现与细胞凋亡、增殖、分化和炎症反应有关。甲基硫腺苷磷酸化酶（MTAP）催化可逆性磷酸解5'-甲基硫腺苷，这是多胺生物合成的副产物。MTAP基因位于周期蛋白依赖性激酶抑制剂2A基因旁边，与CDKN2A基因近15％的肿瘤同时缺失。此外，MTAP缺失的肿瘤细胞对蛋氨酸缺乏和嘌呤合成抑制剂更敏感。在本综述中，我们首先总结了MTAP在肿瘤中的分子结构和表达。此外，我们还讨论了PRMT5和MAT2A作为MTAP缺失肿瘤的潜在易感性。还讨论了MTAP在多种恶性肿瘤中的复杂和动态作用。最后，我们论证了治疗MTAP缺失肿瘤的意义。版权所有© 2023 Fan，Zhang和Zou。

The methionine salvage pathway is responsible for recycling sulfur-containing metabolites to methionine. This salvage pathway has been found to be implicated in cell apoptosis, proliferation, differentiation and inflammatory response. Methylthioadenosine phosphorylase (MTAP) catalyzes the reversible phosphorolysis of 5'-methylthioadenosine, a by-product produced from polyamine biosynthesis. The MTAP gene is located adjacent to the cyclin-dependent kinase inhibitor 2A gene and co-deletes with CDKN2A in nearly 15% of tumors. Moreover, MTAP-deleted tumor cells exhibit greater sensitivity to methionine depletion and to the inhibitors of purine synthesis. In this review, we first summarized the molecular structure and expression of MTAP in tumors. Furthermore, we discussed PRMT5 and MAT2A as a potential vulnerability for MTAP-deleted tumors. The complex and dynamic role of MTAP in diverse malignancies has also been discussed. Finally, we demonstrated the implications for the treatment of MTAP-deleted tumors.Copyright © 2023 Fan, Zhang and Zou.