在赞比亚卢萨卡大学教学医院对肺肿瘤进行病理学特征描述:一项试点研究。
Histopathological characterization of lung tumours at the University Teaching Hospital, Lusaka, Zambia: a pilot study.
发表日期:2022 Dec
作者:
Mizinga Jacqueline Tembo, Violet Kayamba, Ephraim Zulu
来源:
TROPICAL MEDICINE & INTERNATIONAL HEALTH
摘要:
非洲撒哈拉以南地区原发性肺癌的组织学分类数据有限。此外,在赞比亚,肺癌年龄截断发病率的时段趋势按组织学表型分类也是未知的。本研究的目的是确定赞比亚卢萨卡大学教学医院(UTH)肺肿瘤的组织学类型。这是一项肺肿瘤活检的回顾性试点研究,收集了UTH组织病理实验室在一年内所收集的肺肿瘤活检样本。使用标准组织学方法染色并分类肺癌。使用IBM SSPS 23版本分析数据。共检索到23例肺癌组织。组织学类型包括11例(47.8%)鳞状细胞癌(SCC),6例(26.1%)腺癌,2例(8.7%)小细胞癌,2例(8.7%)大细胞癌,1例(4.3%)炎性肌成纤维细胞瘤和1例(4.3%)胸膜肺爆瘤。结果显示,年龄最受影响的群体是60-69岁,该年龄组的大多数组织学亚型是SCC。在年龄组之间的组织学亚型没有统计学上显着差异,p = 0.12。本研究表明,最常见的原发性肺癌类型是鳞状细胞癌。需要更多数据来进一步证实这一观察结果。©2022 Tembo MJ等人。
There are limited data on histological classification of primary lung cancer from sub-Saharan Africa. Furthermore, the time trends of age-truncated incidence rates of lung cancer by histological phenotype in Zambia are also unknown.The objective of this study was to determine histological types of lung tumours at the University Teaching Hospital (UTH) in Lusaka, Zambia.This was a retrospective pilot study of lung tumour biopsies collected from the histopathology laboratory at the UTH over a period of one year. Tissue sections were stained and when seen, lung cancer was classified using standard histological methods. Data were analysed using IBM SSPS version 23.A total of 23 lung cancer tissues were retrieved. Histological types included eleven (47.8%) squamous cell carcinoma (SCC), six (26.1%) adenocarcinoma, two (8.7%) small cell carcinoma, two (8.7%) large cell carcinoma, 1 (4.3%) inflammatory myofibroblastic tumours and 1 (4.3%) pleural pulmonary blastoma. The results showed that the most affected age group was 60-69 years with most of the histological subtype in this age group being SCC. There was no statistically significant difference of histological subtypes across age groups, p=0.12.This study has shown that the most commonly diagnosed type of primary lung cancer is squamous cell carcinoma. More data are needed to further corroborate this observation.© 2022 Tembo MJ et al.