免疫检查点抑制剂免疫治疗用于原发性和转移性脑肿瘤的现状。
The Current Landscape of Immune Checkpoint Inhibitor Immunotherapy for Primary and Metastatic Brain Tumors.
发表日期：2023 Apr 04
作者：
Paolo Alimonti, L Nicolas Gonzalez Castro
来源：
Brain Structure & Function
摘要：
抗免疫检查点抑制剂（ICI）的抗体彻底改变了治疗多种侵略性恶性肿瘤的方式，包括黑色素瘤和非小细胞肺癌。ICI用于治疗原发性和转移性脑肿瘤的效果有所不同。在这里，我们讨论ICI在治疗原发性和转移性脑肿瘤方面的可用证据，重点介绍在神经肿瘤学中推进这种癌症免疫治疗的挑战和机遇。
Antibodies against immune checkpoint inhibitors (ICIs) have revolutionized the treatment of multiple aggressive malignancies, including melanoma and non-small cell lung cancer. ICIs for the treatment of primary and metastatic brain tumors have been used with varying degrees of success. Here, we discuss the available evidence for the use of ICIs in the treatment of primary and metastatic brain tumors, highlighting challenges and opportunities for furthering this type of cancer immunotherapy in neuro-oncology.