Neuritin代表一种神经营养因子，它不仅在神经元发育和可塑性方面非常重要，还影响内皮血管生成，细胞迁移，肿瘤生长和B细胞抗体的产生。我们通过用两种不同的neuritin衍生肽免疫敲除小鼠创造单克隆小鼠抗小鼠neuritin抗体。由于neuritin在物种之间保守性很高，这些新的单克隆抗体可以识别各种物种的neuritin，包括人类。此外，它们不仅可以特异性地识别表面表达的小鼠滤泡区调节T细胞的neuritin，还可以阻止重组neuritin与胚芽中心B细胞的结合。这表明，这些新生成的工具在研究neuritin表达和功能方面将非常有用。

Neuritin represents a neurotrophic factor that is not only important in neuronal development and plasticity but also impacts endothelial angiogenesis, cell migration, tumor growth and the production of antibodies by B cells. We established monoclonal mouse anti-mouse neuritin antibodies by immunizing knock-out mice with two different neuritin-derived peptides. Because neuritin is well conserved between species, these new monoclonal antibodies recognize the neuritin of a wide variety of species, including human. Moreover, they not only recognize specifically surface-bound neuritin expressed by murine follicular regulatory T cells but also the block binding of recombinant neuritin to germinal center B cells. This suggests that these newly generated tools will be of great use in studying neuritin expression and function.