复发还是新发?阴囊表皮内基底细胞癌的两例报告。
Recurrence or de novo? Intradermal Basal Cell Carcinoma of the Scrotum: A Report of Two Cases.
发表日期:2023 Mar 28
作者:
Kaori Yamazaki, Maho Maejima, Hidehisa Saeki, Shin-Ichi Osada
来源:
Cellular & Molecular Immunology
摘要:
基底细胞癌(BCC)是最常见的皮肤恶性肿瘤,通常发生在暴露于阳光的区域。虽然阴囊区的BCC不常见,但其转移的风险比其他部位的BCC要高。在这里,我们报告了两例发生在阴囊区的BCC:第1例表现为浅表性结节,第2例为皮下结节。组织病理学上,两个肿瘤都缺乏与表面表皮的连续性,形成一个皮内结节。在第1例中,BCC首次发生,可能是新发展的。第2例于5年前接受了一次阴囊BCC切除术,那时的组织病理学诊断是结节性BCC。然而,当原标本重新检查时,确定虽然肿瘤已被完全切除,但部分病变已远离结节区域,代表微小结节表型,一种侵袭性BCC亚型。我们假设从结节到微小结节表型的部分演变可能导致了第2例BCC复发。
Basal cell carcinoma (BCC) is the most common cutaneous malignancy, usually occurring in sun-exposed areas. Although BCC in the scrotal region is uncommon, it carries a higher risk of metastasis than BCC at other sites. Here, we report two cases of BCC that developed in the scrotal region: Case 1 presented as a superficial nodule and Case 2 as a subcutaneous nodule. Histopathologically, both tumors lacked continuity with the surface epidermis and formed an intradermal nodule. In Case 1, BCC occurred for the first time and presumably developed de novo. Case 2 underwent excision of a scrotal BCC 5 years previously, and the histopathological diagnosis at that time was nodular BCC. However, when the original specimen was re-examined, it was determined that, although the tumor had been completely resected, part of the lesion had moved away from the nodular area to represent a micronodular phenotype, an aggressive BCC subtype. We hypothesized that partial evolution from a nodular to a micronodular phenotype may have contributed to the recurrence of BCC in Case 2.