ATP依赖的染色质重塑复合物SWI/SNF（又名BAF）在基因表达调控中至关重要。从酵母到哺乳动物的进化过程中，BAF复合物已经演化出了极大的复杂性，包含由各种基因编码的高数量的亚基。新兴的研究突出了改变的哺乳动物SWI/SNF染色质重塑复合物在人类癌症中的频繁参与。在这里，我们讨论了确定SWI/SNF复合物结构的最新进展，突出了影响这些复合物的突变促进癌症的机制，并描述了有希望的新兴治疗机会。© 2023. The Author(s).

The ATP-dependent chromatin remodeling complex SWI/SNF (also called BAF) is critical for the regulation of gene expression. During the evolution from yeast to mammals, the BAF complex has evolved an enormous complexity that contains a high number of subunits encoded by various genes. Emerging studies highlight the frequent involvement of altered mammalian SWI/SNF chromatin-remodeling complexes in human cancers. Here, we discuss the recent advances in determining the structure of SWI/SNF complexes, highlight the mechanisms by which mutations affecting these complexes promote cancer, and describe the promising emerging opportunities for targeted therapies.© 2023. The Author(s).