评估循环性EB病毒（EBV）DNA在淋巴瘤相关性溶血性淋巴组织细胞增多症（HLH）中的作用。我们进行了一项回顾性队列研究，探讨EBV DNA在淋巴瘤相关HLH中的临床和预后意义。通过检索医疗记录系统，我们纳入了2010年1月至2022年11月诊断为淋巴瘤和HLH的成年患者。共识别出281例淋巴瘤相关HLH患者。在其中54.4％（153/281）的患者中观察到高水平的全血EBV DNA，而T / NK细胞恶性肿瘤（199,500，四分位数范围30,000-1,390,000）中的中位数复制数显著高于B细胞非何杰金淋巴瘤（5520，四分位数范围1240-28,400，P＜0.001）。用于预测生存率的最佳截止值为16,100复制/mL。与EBV DNA≤16,100复制/mL的患者相比，EBV DNA＞16,100复制/mL的患者年龄更年轻，T / NK细胞恶性肿瘤更多，中性粒细胞和纤维蛋白原水平更低，血红蛋白，丙氨酸转移酶，天冬氨酸转移酶，乳酸脱氢酶和β2-微球蛋白水平更高。EBV DNA（＞16,100复制/mL），血小板计数＜100×109/L，中性粒细胞计数＜1×109/L，低纤维蛋白原血症（≤1.5 g/L）和肌酸酐升高水平（＞133 μmol/L）负载更高是预测60天总体生存率和总体生存率的独立不良预测因子。基于EBV DNA和其他四个因素建立了一个预后指数，将患者分为四组，具有明显不同的结果。我们的研究确定了高EBV负载作为淋巴瘤相关HLH的危险因素，并建立了一个预后指数来预测结果。©2023年作者专有许可，Springer Science+Business Media，LLC的一部分，属于Springer Nature。

To evaluate the role of circulating Epstein-Barr virus (EBV) DNA in lymphoma-associated hemophagocytic lymphohistiocytosis (HLH).We conducted a retrospective cohort study to explore the clinical and prognostic significance of EBV DNA in lymphoma-associated HLH. We included adult patients with combined diagnoses of lymphoma and HLH from January 2010 and November 2022 by retrieving the medical record system.A total of 281 patients with lymphoma-associated HLH were identified. Elevated whole-blood EBV DNA was observed in 54.4% (153/281) of patients, and the median copy number was significantly higher in the T/NK-cell malignancies (199,500, interquartile range, 30,000-1,390,000) than that in the B-cell non-Hodgkin lymphoma (5520, interquartile range, 1240-28,400, P < 0.001). The optimum cutoff for predicting survival was 16,100 copies/mL. Compared to the patients with EBV DNA ≤ 16,100 copies/mL, those with EBV DNA > 16,100 copies/mL were younger and had more T/NK-cell malignancies, lower levels of neutrophils and fibrinogen, and higher levels of hemoglobin, alanine aminotransferase, aspartate aminotransferase, lactic dehydrogenase, and β2-microglobulin. A higher load of EBV DNA (> 16,100 copies/mL), thrombocytopenia (< 100 × 109/L), neutropenia (< 1 × 109/L), hypofibrinogenemia (≤ 1.5 g/L), and elevated levels of creatinine (> 133 μmol/L) were independent adverse predictors of 60-day overall survival and overall survival. A prognostic index based on EBV DNA and the other four factors was established to categorize the patients into four groups with significantly different outcomes.Our study identified high EBV load as a risk factor for lymphoma-associated HLH and established a prognostic index to predict outcomes.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.