为了寻找乳腺癌新的靶点和治疗方法，我们研究了文献中在乳腺癌有预临床相关研究中具有功效的环状RNA(circRNA)。我们找到了26个上调和6个下调的circRNA，它们在乳腺癌相关的预临床模型中具有功效。我们讨论了已鉴定的circRNA的重构和抑制，以及在药物耐药性、增殖和转移抑制的背景下，靶点的药效和验证。在抑制细胞因子和高迁移率群蛋白、核因子B和Hippo信号通路方面， emerge了作为肿瘤生长和转移的重要驱动因素。在雌激素受体阳性乳腺癌转移方面，三叶因子1的作用也值得进一步研究。此外，黏液19已经成为治疗乳腺癌尚未开发的一个新的靶点。版权所有©2023年，国际抗癌研究所(Dr. George J. Delinasios)，保留所有权利。

In order to identify new targets and treatment modalities for breast cancer, we searched the literature for circular RNAs (circRNAs) with efficacy in preclinical breast cancer-related in vivo models. From our search, we identified 26 up-regulated and six down-regulated circRNAs which mediate efficacy in breast cancer-related preclinical in vivo models. We discuss reconstitution and inhibition of the identified circRNAs, as well as druggability and validation of the targets identified in the context of chemoresistance, inhibition of proliferation and metastasis. Pathways driven by suppressors of cytokines and high-mobility group proteins, nuclear factor B and Hippo signaling emerged as important drivers of tumor growth and metastasis. The role of trefoil factor-1 with respect to metastasis of estrogen receptor-positive breast cancer also merits further investigation. In addition, mucin 19 has emerged as an unexplored target for treatment of breast cancer.Copyright © 2023, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.